The value of blood-based genomic and proteomic testing in patients with lung cancer at the time of initial diagnoses is revealed by a study from Gundersen Health System, La Crosse, Wisconsin.
Non-small cell lung cancer (NSCLC) refers to a group of cancers that share common characteristics but have different genetic features that make them more or less responsive to specific treatments. In this study, genomic and proteomic testing of blood specimens rapidly identified genetic mutations that determined optimal, personalized treatment.
‘Genomic and proteomic testing of blood specimens rapidly identify genetic mutations that determine optimal, personalized treatment for lung cancer.’
Compared with testing of biopsy specimens, the blood tests yielded both important diagnostic information much faster (within 72 hours) regardless of disease stage, and significantly decreasing the wait period between diagnoses and the start of treatment.
"Lung cancer often goes undiagnosed until more advanced stages. Treatment decisions need to be made as quickly as possible. Thanks to recent advances in differentiating cancers based on their genetic and protein biology, treatment of lung cancer is now individualized.
Determining which treatment works best for which patient involves not only considering the tumor's size and spread, but also on its genetic composition. Waiting for test results on biopsy material to determine the correct course of action can delay treatment for several weeks, sometimes months," says lead author Dr. Jennifer Mattingly. "The rapid and accurate results of these tests significantly decreases the wait time between diagnosis and treatment."