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Thanks To Collagen, Elastin, Your Skin Repairs itself from a Wound or Tear Quickly

by Bidita Debnath on  April 6, 2015 at 12:06 AM Research News   - G J E 4
Ever wondered why our skin does not tear under stress? There are four specific mechanisms in collagen — the main structural protein in skin tissue, that acts synergistically to diminish the effects of stress.
Thanks To Collagen, Elastin, Your Skin Repairs itself from a Wound or Tear Quickly
Thanks To Collagen, Elastin, Your Skin Repairs itself from a Wound or Tear Quickly
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"Collagen fibrils and fibers rotate, straighten, stretch and slide to carry load and reduce the stresses at the tip of any tear in the skin," said Dr. Robert Ritchie, study leader from the Lawrence Berkeley National Laboratory (Berkeley Lab) in California. "The movement of the collagen acts to effectively diminish stress concentrations associated with any hole, notch or tear," Ritchie added.

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Skin consists of three layers — the epidermis, dermis and endodermis. Mechanical properties are largely determined in the dermis, which is the thickest layer and is made up primarily of collagen and elastin proteins. Collagen provides for mechanical resistance to extension, while elastin allows for deformation in response to low strains.

The research team began their work by establishing that a tear in the skin does not propagate or induce fracture, as does damage to bone or tooth dentin, which are comprised of mineralized collagen fibrils. What they demonstrated instead is that the tearing or notching of skin triggers structural changes in the collagen fibrils of the dermis layer to reduce the stress concentration.

Initially, these collagen fibrils are curvy and highly disordered. However, in response to a tear they rearrange themselves towards the tensile-loading direction, with rotation, straightening, stretching, sliding and de-lamination prior to fracturing.

"The rotation mechanisms recruit collagen fibrils into alignment with the tension axis at which they are maximally strong or can accommodate shape change," Meyers explained. Straightening and stretching allow the uptake of strain without much stress increase, and sliding allows more energy dissipation during inelastic deformation.

"This reorganization of the fibrils is responsible for blunting the stress at the tips of tears and notches," he added.

The study appeared in Nature Communications.

Source: IANS
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