Patients taking HIV and Hepatitis B drugs had a 33% lower risk of developing diabetes. Lamivudine improves insulin sensitivity significantly in human cell samples and in a mouse model of diabetes in the new study. "The fact that the protective effect against the development of diabetes was replicated in multiple databases in studies from multiple institutions enhances confidence in the results," said researcher Jayakrishna Ambati, MD, of the University of Virginia School of Medicine.
‘Inflammasome inhibitors known as Kamuvudines, which are less-toxic derivatives of NRTIs, will be effective in diabetes, macular degeneration and Alzheimer's disease.’
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The Diabetes Pandemic
Nearly 500 million people worldwide have diabetes - primarily type 2 diabetes - and that number is expected to soar in the coming years. This carries a tremendous health burden, as diabetes is associated with many chronic medical conditions, including heart disease, atherosclerosis (hardening of the arteries), nerve damage, vision loss and impaired wound healing.
The urgency of the situation has scientists desperately hunting for better ways to prevent and manage diabetes. To determine if drugs known as nucleoside reverse-transcriptase inhibitors (NRTIs) might help, Ambati and colleagues from multiple institutions analyzed five databases encompassing a diverse group of 128,861 patients with HIV-1 or hepatitis B.
The primary database consisted of the Veterans Health Administration, the largest integrated health system in the United States, and was reviewed from 2000 to 2017.
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To better understand the findings, the researchers examined the effect of lamivudine and two other drugs from the class in human cell samples. All three proved beneficial, prompting the scientists to conclude that the class as a whole is likely helpful in preventing diabetes.
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"We are hopeful that prospective clinical trials will establish that inflammasome inhibitors known as Kamuvudines, which are less-toxic derivatives of NRTIs, will be effective not only in diabetes but also in macular degeneration and Alzheimer's disease."
Source-Eurekalert