Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Higher Expression of Factors Linked With Nerve Growth Observed in Pancreatic Cancer | |
|
| |
A study of pancreatic cancer in laboratory mice has identified higher expression levels of four factors involved in the growth and maintenance of nerves.
"When other researchers have looked at samples of pancreatic cancer, they have described perineural tumor invasion in as many as 90 to 100 percent of cases," said Rachelle E. Stopczynski, a M.D./Ph.D. student at the University of Pittsburgh in Pa. "We used a mouse model of pancreatic cancer to look at what drives these interactions, and to investigate what role tumor-nerve interactions play in cancer progression."
She presented these findings at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21.
Stopczynski and colleagues measured the levels of neurotrophic factors, which are proteins in charge of the growth and maintenance of nerve cells, in the pancreata of mice with a condition modeling pancreatic cancer and healthy controls aged between 16 and 30 weeks. They also measured the density and distribution of nerve fibers in the pancreas and observed levels of physical activity.
Expression levels of four neurotrophic factors were higher in the pancreata of mice with pancreatic cancer. Nerve bundles were also observed to be larger and the overall physical activity undertaken by the mice with pancreatic cancer was reduced.
This adds important information to our understanding of pancreatic cancer, especially since not all cancers invade peripheral nerves as pancreatic tumor cells do, and not all cancers cause the same level of visceral pain, according to Stopczynski.
"A tumor invading a nerve is going to damage that nerve, causing pain. The nerve can also shield the tumor cells from chemotherapeutic drugs, while at the same time serving as a pathway for tumor cells to spread to other organs. Therefore, these interactions could be responsible for different aspects of cancer progression as well as the development of pain," she said.
Source-Eurekalert
| |
|
|
More News on: Pancreatic Cancer, Cancer and Homeopathy, Cancer Facts, Cancer, Tattoos A Body Art, Pancreatitis, Von Recklinghausen's Disease, Brachial Plexus Injury
 Comment & Contribute
|
Related Links
Use of Swedish 'snus' is Linked to a Doubled Risk of Pancreatic Cancer
People who use Swedish moist snuff (snus) run twice the risk of developing cancer of the pancreas. This is the main result of a follow-up study ...
Roche Calls For Re-Examination Of Tarceva Data By EU Authorities
Roche Holding AG announced today that it has asked EU health authorities to re-examine data related to approving the pancreatic cancer treatment ...
Better Care for Neuroendocrine Cancer Possible Via PET Imaging
Researchers have revealed that a method of molecular imaging that pinpoints hormonally active tissues in the body could change the course of ...
Cancer Related News
India Gets Advanced Breast Cancer Detecting Machine
In the national capital, an advanced digital breast cancer detecting machine with the capability to see the lesions in breasts with much more clarity ...
New Method can Help Distinguish Pancreatic Cancer from Pancreatitis
In a promising development that could help improve the accuracy of pancreatic cancer diagnosis, researchers at Mayo Clinic have come up with a new ...
Link Between Agent Orange Exposure and Prostate Cancer
A new study has now linked the exposure to Agent Orange and lethal forms of prostate cancer among the US Veterans. Published early online in ...
Tumour Growth Mechanism Goes a Step Further
New study suggests that loss of a particular tumour-suppressing protein causes abnormal growth of tumours of the brain and nervous system. ...
Link Between Skin Cancer and Lower Risk of Alzheimer's Disease Identified
According to a recent study people who have skin cancer are at a reduced risk of developing Alzheimer's disease. The link does not apply to melanoma, ...
Molecular Profiling Timely for Tailoring Therapy Shown By First Prospective Trial
Patients, and their physicians, are eager to jump into next-era cancer care analysis of an individual's tumor to find and target genetic mutations ...
- Health News Index
 | Quiz on Cancer Looking for information on cancer? Go through medindia's Cancer quiz. 
|
- News Quick Links
 |
Cancer
Complete Medindia Resources
|
| News Categories: |
| » | Mediterranean Diet Boosts Ageing Brain Power |
| » | Eating Disorders on the Rise |
| » | 24 Karat Gold Tea Introduced |
| » | Go for the White Veggies as Much as You Go for the Colorful Ones |
| » | Health Benefits of Dark Chocolate Revealed |
| More Diet News | |
|
Ask an Expert
