Heat Production of Brown Fat may Ward Off Obesity

by Julia Samuel on  April 15, 2016 at 4:02 PM Obesity News
RSS Email Print This Page Comment
Font : A-A+

Impaired brown adipose tissue (BAT), otherwise known as 'brown fat', drives obesity, and by stimulating heat production in this fatty tissue, weight-management and glucose tolerance can be improved.
Heat Production of Brown Fat may Ward Off Obesity
Heat Production of Brown Fat may Ward Off Obesity

For the first time scientists have kick-started the natural process by which genetically predisposed obese mice gain weight, opening up a new potential approach to fight off obesity.

Worldwide obesity has more than doubled since 1980. In 2014, there were over 600 million people classified as obese, making up 13% of the global population. Obesity is now classified as an 'epidemic' by the World Health Organization and immediate action is being called for.

"The results of our study show that certain cellular impairments found in one's metabolic make-up increases the likelihood of obesity and the associated issues, such as diabetes and high blood pressure," said study lead author, Laurence Poekes, University; Catholique de Louvain, Bruxelles, Belgium. "By intervening to reverse such impairments using a mouse model, we believe effective therapeutic strategies could be developed to combat obesity and associated comorbidities."

In the study, male foz/foz mice were studied as they are prone to developing metabolic syndrome, which is characterised by obesity, high blood pressure and diabetes. The foz/foz mice were studied alongside wild-type mice, that do not have the same metabolic predisposition. Metabolic syndrome in foz/foz mice was associated to impaired thermogenesis in BAT in response to high fat diet feeding or to cold exposure. This could contribute to lower energy expenditure and increase fat storage.

To stimulate BAT activity in the overweight foz/foz mice, intermittent cold exposure (4°C, 2h/day, 5 days/week), β3-adrenergic agonist treatment (CL-316,243, 1mg/kg/day) and brown adipose tissue (BAT) transplantation from wild type mice were performed.

The results showed that for the foz/foz mice that had stimulated BAT activity, they experienced decreased body weight gain (11g vs 16g, p<0.001) and improved glucose tolerance (p<0.001) compared to untreated foz/foz mice.

"This study uncovers a smart approach that could help the medical community develop effective interventions to address our global population's obesity epidemic," says Professor Tom Hemming Karlssen, EASL Vice-Secretary. "I look forward to seeing this approach further investigated in future research."



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Bariatric Surgery Cholesterol Obesity Diabetes - Essentials Binge Eating : The Pleasure and Pain Bulimia Nervosa Diet Lifestyle and Heart Disease Body Mass Index Cholesterol - The Enigma Chemical Liposuction 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive