Scientists have always believed that the mammalian heart lacks the ability to repair itself after injury.
However, a 2011 study in newborn mice challenged this view, providing evidence for complete regeneration after resection of 10% of the apex, the lowest part of the heart. In a study published by Cell Press in Stem Cell Reports
on April 3, 2014, researchers attempted to replicate these recent findings but failed to uncover any evidence of complete heart regeneration in newborn mice that underwent apex resection.
"Our results question the usefulness of the apex resection model for identifying molecular mechanisms underlying heart regeneration after damage and underscore the need for the scientific community to firmly establish whether or not the mammalian heart is capable of regeneration," says lead study author Ditte Andersen of Odense University Hospital and the University of Southern Denmark.