Western Diet During Pregnancy Increases Lifelong Obesity Risk in Offspring

Highlights

• Diet composition around the time of pregnancy may influence whether offspring can become obese.
• A typical American, or Western diet appears to increase the risk of lifelong obesity.
• The Western diet sets in motion a metabolic program that lasts throughout the life in mice.
The type of food you eat during pregnancy may influence the risk of obesity in offspring and this can have a lifelong risk of obesity in mice according to a new study using animal models at The Scripps Research Institute (TSRI).
Giving females a typical American, or Western, diet appeared to set the next generation up for lifelong obesity issues. 


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‘Overweight mothers were more likely to have overweight offspring but the new findings suggest that diet alone can make a difference independent of weight gain.’

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"Your diet itself matters, not just whether you are gaining excess weight or developing gestational diabetes," said TSRI Associate Professor Eric Zorrilla, who led the study in collaboration with Tim R. Nagy of the University of Alabama at Birmingham and Barry E. Levin of the Veterans Affairs (VA) Medical Center of East Orange, New Jersey, and Rutgers University. 

The researchers made this discovery by studying two lines of rats, one selectively bred to be obesity-resistant to a high-fat diet and one bred to be unusually vulnerable. Rats from each group were fed either a diet with the same overall fat, saturated fat, carbohydrate and protein levels as a typical Western diet, or a lower-fat, higher-grain control diet. 

The scientists found that female rats given a Western diet in the weeks leading up to pregnancy, during pregnancy and during nursing had offspring more prone to obesity at birth, during early adolescence and--many months later--through adulthood. This occurred even if the mothers themselves did not overeat and maintained a healthy weight, body fat and insulin status. 


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Previous studies had shown that overweight mothers were more likely to have overweight offspring, the new findings suggest that diet alone can make a difference independent of weight gain. 

The Western diet seemed to set in motion a metabolic "program" that lasted throughout the rat's life. Although these rats slimmed down during puberty and early adulthood, they still showed a lower basal metabolic rate (less energy expended at while rest) and higher food intake during that time, which led to a return of obesity in mid-adulthood. 


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"What we found interesting was that you sometimes see the same thing in humans, when a kid goes through a growth spurt," said study first author Jen Frihauf, University of California, San Diego. The researchers also identified elevated levels of several molecules, such as insulin and hormones called leptin and adiponectin, starting at birth in both the Western diet and genetically vulnerable offspring. This hormone profile may serve as an early biomarker for detecting obesity risk. 

Research is ongoing into which aspects of a Western diet trigger these effects--and the molecular changes in the offspring responsible for them. Zorrilla said the findings should raise awareness of the importance of a healthy pre- and post-natal diet. For example, doctors may want to discuss nutrition with all women who are pregnant or are planning to become pregnant, not just those already overweight. 


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"Doctors often use weight gain as a hallmark of a healthy pregnancy. But we realized there was something going on in utero that wasn't detectable in the mother's weight,"said Frihauf.

The researchers also spotted an interesting difference in the effects of the Western diet between the obesity-vulnerable and obesity-resistant lines: in females, the diet impaired the reproduction of the obesity vulnerable lines. Significantly fewer of females were able to reproduce, and those that did reproduce had fewer offspring.  

"This wasn't the focus of the study, but it supports the idea that a Western diet promotes infertility in mothers vulnerable to diet-induced obesity," said Zorrilla. 

Frihauf added that few pregnant women, even in the United States, eat a high-fat, high-sugar diet all day, every day. "We're not trying to tell pregnant women not to occasionally splurge on a piece of cake," she said. 

Zorrilla concluded that paternal diet, through epigenetic mechanisms that control how genes are expressed, can affect obesity risk in offspring, so nutritional information may be valuable for potential fathers as well.

Reference

1. Jennifer B. Frihauf et al. Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markersAmerican Journal of Physiology - Regulatory, Integrative and Comparative Physiology ,Vol. 311 no. 6, R1045-R1059 (2016),DOI: 10.1152/ajpregu.00023.2016.


Source-Medindia