protein hormone, constituting around 0.01% of the plasma proteins is produced
by the fat tissue and regulates the metabolic activities like glucose
regulation and fatty acids catabolism. It has also been found to have
anti-inflammatory effects and reduce insulin resistance and the risk of cardiovascular
It is an established fact that adiponectin level is
greatly reduced with increased body fat percentage.
And higher fat
percentage is correlated with increased risk of type2 diabetes mellitus and
A study tried to establish the
association between adiponectin and salivary pH in women.
salivary pH in women is lesser than that compared to men and is affected by the
The study included
151 Caucasian women with 53 pre-menopausal women in one group and 98 menopausal
women in the other. Salivary pH and plasma adiponectin levels were analyzed in
both the groups.
The researchers found that the salivary pH
varied in proportion to the plasma adiponectin levels in women in both the
groups but showed a prominent linear relationship in menopausal women.
There were certain limitations to the findings.
Previous conditions like insulin resistance and
hyperlipidemia, which could influence the adiponectin levels and salivary pH,
were not taken into account.
The study involved only women and was based on the
menopausal status thus limiting the use of salivary pH as a biomarker in health
With obesity, type2 diabetes
and cardiovascular diseases becoming a worldwide epidemic, saliva sampling
could prove to be an easy and inexpensive diagnostic and screening method for
health assessment. Further studies are required in this regard.
Reference: Salivary pH as a Marker of Plasma
Adiponectin Concentrations in Women; Monique et al; Diabetology and Metabolic