Metabolic syndrome is also known
as metabolic syndrome X, cardiometabolic syndrome, insulin resistance syndrome,
syndrome X, CHAOS (in Australia) and Reaven's syndrome. It is a cluster of medical
disorders that together increases the risk of developing diabetes and
cardiovascular ailments. Generally, metabolic syndrome patients are overweight
of any three of the following traits in an individual increases his/her
chances of developing metabolic syndrome.
1.A decrease in serum HDL cholesterol (40mg/dl or less in men
and 50mg/dl or less in women)
2.Increase in serum triglycerides (150 mg/dl or
3.Presence of high blood pressure (130/85 mm of Hg
4.Fasting glucose level of 100mg/dl or more
Dallmeier et al conducted a community-based cross-sectional study that was
published in the journal of Diabetology and Metabolic Syndrome 2012. The study
aimed at investigating the association between metabolic syndrome and
inflammatory biomarkers- interleukin-6, intercellular adhesion molecule-1,
C-reactive protein, CD40 ligand, osteoprotegerin, tumor necrosis factor
receptor-2, monocyte chemoattractant protein-1, P-selectin and tumor necrosis
factor-α, were measured in 2570 participants of the study. The volunteers were
free of cardiovascular ailments and diabetes.
study revealed the presence of metabolic syndrome in 984 participants and was
found to be associated with each inflammatory biomarker except osteoprotegerin,
thus proving that metabolic syndrome is associated with inflammation even in
the absence of obesity. "After adjusting for its components, the metabolic
syndrome was only associated with P-selectin."
study showed the existence of relationship between inflammatory biomarkers and
metabolic syndrome. By making adjustments for each component of the metabolic
syndrome the relationship between biomarkers and metabolic syndrome was
eliminated except for P-selectin.
researchers concluded, "Our results support the hypothesis that the relation
between metabolic syndrome and inflammation is largely accounted for by its
Though the findings of the study
do not have any immediate clinical significance, further studies in this area
could help to find out if measuring inflammatory mediators can predict the
development of metabolic syndrome. This could help to institute preventive
measures at the earliest.
Metabolic Syndrome and Inflammatory Biomarkers:
a community-based cross-sectional Study at the Framingham Heart Study; Dhayana
Dallmeier et al; Diabetology and Metabolic Syndrome 2012