Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Pathways Between Inflammation and Depression are Bi-Directional: Review Study | |
|
| |
Negative moods can
activate certain mechanisms in the body that result in up-regulation of
inflammation and again, inflammatory substances bring about changes in the
brain that cause major depressive disorder, according to a study published in
the journal Biology of Mood & Anxiety Disorders. Thus, pathways between
inflammation and depression are bi-directional.
Systemic disorders contribute to the mental health of the patient. Depression can reduce the functional parameters of immune system. Meanwhile innate, non-specific inflammation is related to depressed moods. Chronic age-related systemic diseases can cause reasons for morbidity of depression in advanced age groups.
Inflammation is an immune response to any pathogens or tissue damage mediated by macrophages which are large white blood cells involved in the body's defense mechanism. These release pro-inflammatory cytokines that causes inflammatory response.
Depression is a mental disorder with commonly seen symptoms such as loss of interest, low energy, disturbed sleep or appetite and poor concentration.
Pro-inflammatory cytokines such as interleukin (IL)-6, IL-1b, and especially, tumor necrosis factor (TNF)-alpha are known to have effects on depressed moods. Animal studies have shown that peripheral pro-inflammatory cytokines could penetrate the blood brain barrier and stimulate the production of central pro-inflammatory cytokines that regulates the moods. When humans were administered immune stimulating endotoxins that cause low-grade inflammation, episodes of major depression was recorded. Hence increased level of cytokines in blood is related to the symptoms of depression.
Negative mood causes high level of circulating pro-inflammatory cytokines. Depression activates the hypothalamic-pituitary-adrenal axis that leads to release of cortisol, which aggravates sympathetic stimulus (the fight or flight response) and reduces parasympathetic stimulus (the rest and digest response). This increases pro-inflammatory cytokines in blood which then cause inflammation in the body.
Hence this is a complex feedback network involving central nervous system, endocrine system and immune system. These act in modulation of peripheral inflammatory response to maintain peripheral homeostatic balance.
Source: http://www.biolmoodanxietydisord.com/content/pdf/2045-5380-2-4.pdf
Source-Medindia
| |
|
|
More News on: Adolescence Depression, Depression, Stress Relief Through Alternative Medicine, Andropause / Male Menopause, Pregnancy and Complications, Bereavement, Holistic Management for Depression, Tourette Syndrome, Dealing with Menopause symptoms through lifestyle changes, Tired All The Time
 Comment & Contribute
|
Related Links
Depression Screening Test
Depression Screening Test is a simple online screening test to find out if you are suffering from Depression and need to seek ...
Inflammation and Depression
Researchers are in the process of finding out whether inflammation in the body is a consequence of or contributor to major depression. ...
Researchers Link Depression To Chronic Brain Inflammation
Researchers from University of California, San Diego School of Medicine have said that chronic depression originates from more ancient ...
Health Watch News
How Much Vitamin D is Needed for Infants?
We all know very well that vitamin D or 'the sunshine vitamin' is required for the growth and development of healthy bones. In the initial ...
You Will Invite Hatred by Fat Talk
You might be conscious about being overweight but make a point to avoid talking about your obesity with others, as nobody likes it or is interested ...
Dual Parenting More Beneficial Than Single Parenting, Shows Brain Research
Canadian research suggests that dual parenting may be more beneficial than single parenting. It may offer the advantage of enhancing brain cell ...
Status of Elderly In-Hospital Cardiac Arrest Survivors
It is now well known that cardiac arrest survivors suffer severe emotional and mental stress. The survivors also experience some degree of ...
Outdoor Activity Reduces Chances of Developing Nearsightedness in Kids
Two new studies published in the journal Ophthalmology reveal that spending time outdoors may help prevent or minimize nearsightedness ...
Bone Health in Children Requires Magnesium Along With Calcium
Whenever parents think of bone health of their child, the first thing that comes to their mind is calcium. It looks like magnesium too has an ...
- Health News Index
|
|
 | Quiz on Depression Depressed people talk of suicide. Should you press the panic button or seek medical help? What are the symptoms of depression? Why do we get depressed? To find out take this quiz on depression. 
|
- News Quick Links
 |
Depression
Complete Medindia Resources
|
| News Categories: |
| » | Link Between Agent Orange Exposure and Prostate Cancer |
| » | Tumour Growth Mechanism Goes a Step Further |
| » | Link Between Skin Cancer and Lower Risk of Alzheimer's Disease Identified |
| » | Molecular Profiling Timely for Tailoring Therapy Shown By First Prospective Trial |
| » | Broad Support for Rationing of Some Types of Cancer Care Found By Penn Medicine Study |
| More Cancer News | |
|
Ask an Expert
