New Susceptibility Loci for Osteoarthritis Identified: A Genome-wide Association Study

by Dr. Poonam Kuruganti on  July 24, 2012 at 4:30 PM Health Watch
RSS Email Print This Page Comment bookmark
Font : A-A+

Osteoarthritis, a common type of arthritis, often leads to pain and disability in the older population. It is a multifactorial musculoskeletal disease with hereditary and environmental influences. Previous studies identified 3 of 11 genetic sites linked with osteoarthritis in European patients.
New Susceptibility Loci for Osteoarthritis Identified: A Genome-wide Association Study
New Susceptibility Loci for Osteoarthritis Identified: A Genome-wide Association Study

The current Genome-Wide Association Study (GWAS) of osteoarthritis, part of the Arthritis Research UK Osteoarthritis Genetics (arcOGEN) Consortium, was conducted in several thousands of unrelated osteoarthritis and population-based unrelated control patients.

The meta-analysis identified eight genetic loci with a link to increased risk of osteoarthritis occurrence. These included rs6976 on chromosome 3, and the loci close to ASTN2 (chromosome 9), between FILIP1 and SENP6 (chromosome 6), close to KLHDC5 and PTHLH (chromosome 9), close to CHST11 (chromosome 12) and the FTO gene.

These joint-specific inherited factors do influence osteoarthritis development and progression. The association of osteoarthritis with the FTO gene (the gene related to obesity) reiterates the fact that osteoarthritis is associated with body excess weight.

Thus, the newly discovered genetic influences contribute to increased risk for osteoarthritis and provide new targets for therapeutic action.

Reference: Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study; arcOGEN contributors; The Lancet Online Publication July 2012

Source: Medindia

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Osteoarthritis Hypermobility Syndrome Back Pain at Workplace: Prevention and Exercises Knee Replacement Surgery Diet, Nutrition and Supplements for Osteo-Arthritis and Rheumatoid Arthritis Hip Replacement Surgery Avascular Necrosis Psoriatic Arthritis Stickler Syndrome 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...