Does Obesity in Adolescent Boys Pose A Future Risk of Liver Disease, Cancer?

Highlights

The increased prevalence of weightgain and obesity around the world could lead to an increase in cases of severe liver disease in the future.
Men with obesity and type 2 //diabetes were found to be more than three times more likely to have liver problems when they are older.
Screening of men with type 2 diabetes mellitus for presence of manifest liver disease using non-invasive, inexpensive scoring systems could be a way forward.

The risk of high body mass index (BMI) being a marker for developing severe liver disease later in life seems to be present from an early age, and is heightened by the development of type 2 diabetes.

Overweight and obesity levels are increasing globally and around 1 billion people are now projected to be obese (defined as having a BMI higher than 30 kg/m2) by 2030. A high BMI is associated with an increased risk for future severe liver disease and liver cancer in adults, while also increasing the risk for type 2 diabetes, which is, in turn, linked to a higher risk of severe liver disease.

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‘High BMI in late adolescence is associated with future severe liver disease and cancer. The risk is even higher in men who develop type 2 diabetes over the years.’

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Higher BMI, Higher the Risk of Liver Disease

The link between BMI and liver disease was not examined in a previous study which has shown that a high BMI in late adolescent men is associated with an increased risk of death in, or hospitalisation for, end-stage liver disease. Even when other factors are taken into account - such as alcohol consumption, smoking and use of narcotics, the risk remained high.

Researchers led by Dr Hannes Hagström, of the Centre for Digestive Diseases at the Karolinska University Hospital, Stockholm, Sweden set out to investigate how BMI in early adolescents impacted on liver problems later in life.

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They used register data from more than 1.2 million Swedish men enlisted for military conscription between 1969 and 1996. They also linked data on severe liver disease, liver cancer and type 2 diabetes during follow-up from population-based registers. The men were followed up from one year after conscription until 31 December 2012.

Results showed that during follow-up there were 5,281 cases of severe liver disease including 251 cases of liver cancer. The researchers discovered that overweight men were almost half as likely and obese men more than twice as likely to develop liver disease in later life than men of normal weight.

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Men who developed type 2 diabetes had an even higher risk. Men with obesity and type 2 diabetes were more than three times more likely to have liver problems when they were older compared with non-diabetic, normal weight men.

Bottom line

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This was an observational study, so no firm conclusions can be drawn about cause and effect. However, the researchers said it was likely that the increased prevalence of overweight and obesity around the world could lead to an increase in the total number of cases with severe liver disease in the future, including an increasing incidence of liver cancer.

"Interventions to reduce the increasing prevalence of overweight and obesity should be implemented from an early age to reduce the future burden of severe liver disease on individuals and society."

They conclude, "This could have implications for public health decision making, strengthening the need of targeted intervention against overweight and obesity at an early age and specifically highlights the risk of type 2 diabetes mellitus as a risk factor for liver disease.

Reference

Hannes Hagström et al., High BMI in late adolescence predicts future severe liver disease and hepatocellular carcinoma: a national, population-based cohort study in 1.2 million men, Gut (2017) http://gut.bmj.com/content/early/2017/02/28/gutjnl-2016-313622.

Source-Medindia