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Stem Cell Treatment for Osteoarthritis of Knee Joint

by Dr. Trupti Shirole on  October 27, 2010 at 2:24 PM Health Watch   - G J E 4
Osteoarthritis is a degenerative condition of cartilage loss. It is the leading cause of knee joint pain and disability among the elderly and affects over 10 million people in the US. Over the last few years, several methods have been developed techniques to trepair the damaged cartilage of the knee joint .
 Stem Cell Treatment for Osteoarthritis of Knee Joint

Scientists at the University of Bristol report some success with stem cell therapy for the treatment of osteoarthritis damage in knees.

Similarly, according to scientists at the Cardiff University, stem cells can be turned into cartilage cells and this cartilage can be transplanted in an affected joint.

Stem cells can be obtained from:

• Embryonic stem cells

• Normal healthy volunteers

• Autologous stem cells are obtained from bone marrow in the iliac crest of the same individual.

These British scientists have concluded that osteoarthritis does not stop the cell regeneration process, so knee cartilage injuries can be effectively repaired by tissue engineering.

The study has proved that engineered cartilage tissue formed from the stem cells can grow and mature when implanted into patients with a knee injury. Therefore the scientists believe that the tissue engineering approach can be beneficial for cartilage regeneration even in knees affected by osteoarthritis.

ARC Professor of Rheumatology & Tissue Engineering at the Bristol University, Anthony Hollander said that tissue-engineered cartilage implanted into knees showing signs of osteoarthritis can mature within a year after implantation.

Professor Anthony Hollander and his team have been successful in autologous stem cell transplant i.e. growing human cartilage from a patient's own stem cells. Implanting such cartilages grown from the stem cells of the same person avoids immune rejection problems.

Successful repair of osteoarthritis cartilage damage depends on its ability to form a matrix within the joint.

During the study some patients did not benefit from this treatment. According to Professor Hollander the reason why not all patients benefited from the engineered cartilage is not yet totally clear. But he believes that giving the engineered tissue a longer time to settle in may be helpful.

Older patients with osteoarthritis have cartilage that is less responsive to stem cell stimulation. Their stem cells respond less to usual growth factors.

Scientists used stem cells obtained from the bone marrow. It took about a month to grow these stem cells into a cartilage of half-inch length.

An American team of scientists is also studying a stem cell approach using a single donor for multiple patients.

With multiple teams doing human clinical trials in this area the development of successful joint repair using stem cell therapies is not a distant prospect.

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It is good news for most of the people with knee joint pain BUT not for all as it looks from reading different article. Now the question is "Is it approved b FDA?" and how safe is it. Are there any side effects in the long run. I am living in Saudi Arabia hailing from India. Is it available in the middle east or in India? hmohi
hmohi Wednesday, December 25, 2013
Are any PRP sites accepting volunteers for knee treatment? I am retired, healthy, athletic. The cost for PRP is prohibitive for me. But, I do not want to undergo joint replacement. I live in New Jersey.
Yknotfish Thursday, December 12, 2013
I am a 67 year female. Nurse. I have always been very athletic. I would love to be a part of the trials. I live about 70 miles south of st.louis Washington university. My phone # is 573 330 5565. Please let me know if you have info for me. Thanks cosondra.
cosondra45 Tuesday, May 28, 2013
My son went and talked to a physican in PA regarding stem cell treatment, insurance companies do not pay for this proceudre becuase it is still new in this country, he is categoriezed a 3 for this procedure which the doctor said that he is a poor candidate for this, I would like to know is it worth payinf for this procedure if the doctor said he is a poor candidate it is around $7 grand?
chesapeake25 Wednesday, August 29, 2012
Has anyone had this procedure covered by insurance?
Nakita Thursday, May 10, 2012
where is this being done in the U.S. ?
bumknee Saturday, April 28, 2012
How do I become a volenteer for research study so that I may avoid knee replacement, send me as much infor as possible
leslie61 Monday, January 23, 2012
My mother is suffering from Osteoartritis. Is stem cell therapy available in India and if so then the contact details of Doctors undertaking this treatment.
SanjayMehan Monday, January 09, 2012
Hi all, my name is Sanjeev Hegde from India. I am a Known hemophilic with factor viii deficiency. Due to repeated bleeding in my right knee joint my joints have become weak and doctors have told it has turned to osteoarthritis. its very painful and depressing while walking. so can i go for cell therapy? will it help me in regenrating cartilge? please guide regarding this.
sanjeev_hegde Wednesday, December 14, 2011

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