Earlier, studies investigated the connection
between smoking, alcohol, or physical activity and the risk of getting unstable
angina pectoris (UAP).Now the researchers investigated whether the associations
of certain lifestyle factors with unstable angina pectoris varied from those
with acute myocardial infarction (AMI). Furthermore, it was also taken into
consideration if these effects differed between individuals with and without a
family history of MI.
The studyconsisted of 21,148 participants, aged
20-59 years whowere randomly selected from Maastricht and other nearby
surrounding communities in 19871997. The participants had to fill up a
questionnaire based on medical history, family history of MI and lifestyle
factors (like smoking, alcohol consumption and physical activity).During a physical
examination, their height, weight, blood pressure were measured. Blood samples
were taken for determination of total and HDL cholesterol levels. After
follow-up of approximately 17 years, 420 AMI, and 274 UAP cases were
registered.
It was found that lifestyle factors affected the
risk of both the diseases. For both the diseases, smoking increased the risk
while alcohol consumption was associated with a protective effect. The
difference in the risk factors was only statistically significant for smoking. The
number of cigarettes smoked was directly proportional to the risk of both
coronary diseases.
In men, an inverse association was found with
physical activity during relaxation which seemed to be stronger for the risk of
UAP than of AMI. On the other hand in women, physical activity during leisure
time was associated with an increased risk of both AMI and UAP. Nonetheless,
the highest levels of risk factors were found in individuals with a positive
family history and the most unfavorable level of the lifestyle factors.
The effects
of the lifestyle factors on the risk of both the coronary diseases were the
samefor subjects, with and without a positive family history.
Reference:
http://www.biomedcentral.com/content/pdf/1471-2261-11-13.pdf
Source-Medindia