1. Benzonatate (Tessalon):
Benzonatate is a local anesthetic used to control cough. Accidental ingestion has resulted in death
in some children less than 10 years of age.
2. Dronedarone hydrochloride
Dronedarone is a drug used to treat arrhythmias or abnormal heart rhythms. It has been reported to increase the
anticoagulant effect of warfarin when the two drugs were used together.
3. Epoetin alfa
Epoetin alfa is human recombinant erythropoietin that stimulates the
production of red blood cells. The
formulation of epoetin alfa was reported to be contaminated with small glass
flakes called lamellae. The lamellae
could cause adverse effects like increased blood clotting and local
reactions. The manufacturing company
Amgen has recalled certain lots of the drug due to this contamination.
4. Gemcitabine hydrochloride
Gemcitabine is an anticancer drug. It has been reported to cause veno-occlusive
liver disease or blockage of small hepatic veins.
5. Lanreotide acetate
Lanreotide is a drug similar to
a hormone found in the body called somatostatin. It is used to treat adult patients suffering from excess growth
hormone, a condition called acromegaly.
It has caused severe cases of pancreatitis.
6. Lanthanum carbonate
Lanthanum carbonate is used to reduce phosphate levels in the blood in patients
with kidney failure. However, it has
caused swallowing complications and obstruction in the digestive tract due to
hardness of the tablet
7. Levetiracetam (Keppra):
Levetiracetam is a drug used in the treatment of seizures. It has caused severe skin reactions like
Stevens-Johnson's Syndrome and Toxic Epidermal Necrolysis.
8. Lithium citrate
: Lithium citrate is used for a psychiatric condition called manic
depressive psychosis. It has been found
to increase the risk of certain patients manifesting a condition called Brugada Syndrome
. Brugada Syndrome is a hereditary condition
in which the patient suffers from ECG changes and sudden cardiac death.
9. Lopinavir/Ritonavir oral
This antiHIV formulation has
been reported to cause serious adverse effects in neonates.
10. Octagam 5%, Immune Globulin
This formulation has been
reported to cause increased cases of thromboembolism or blood clots. This formulation has been voluntarily
withdrawn from the US market by its manufacturer.
11. Pioglitazone HCl (Actos):
Pioglitazone is an anti-diabetes drug that could be associated
with severe muscle damage, a condition called rhabdomyolysis. The condition often progresses to kidney
12. Ranolazine (Ranexa):
Ranolazine is a drug used
to treat angina or chest pain due to reduced blood supply to the heart. It has been found to increase the risk of
rhabdomyolysis in patients taking cholesterol lowering drugs from the statin
13. Sodium oxybate (Xyrem
): Sodium oxybate is a
central nervous system depressant that has been reported to cause death in some
Though the FDA is closely monitoring these drugs for
their side effects, it has advised patients and physicians to continue to use
the drugs, till these adverse effects are established and further regulations
are in place.