New research emphasizes the significance of carrying out
kidney-sparing surgery on patients with renal cancer to preserve kidney
function and to minimize the risk of bone fractures later in life.
The study performed by researchers at the University of California, San
Diego School of Medicine was published in the July 19 edition
Derweesh, MD, senior author and urologic oncologist at UC San Diego
Moores Cancer Center said, "When weighing the risks and benefits of partial
versus radical nephrectomy, doctors and patients should take into account the
impact on a patient's bone health".
"This study illuminates the fact that preserving
the kidney helps to prevent chronic kidney disease and significantly reduces
bone fractures and risk of developing osteoporosis", he said.
Complete /Partial Nephrectomy
Renal cell carcinoma is a kind of
kidney cancer and nephrectomy is one of the treatment methods used to treat the
But of late, with advancements in medical
technology, kidney-preserving treatments are the preferred mode of treatment
for small renal masses.
When compared to radical nephrectomy, they offer
the same cure rates and offer better
kidney function protection.
The total removal of a kidney, nephrectomy, is
understood to be a significant risk factor for chronic kidney disease (CKD). This in turn, increases a person's
risk for metabolic complications, cardiovascular disease and even death.
When partial nephrectomy is carried out, healthy
and viable kidney cells are preserved. This can help to reduce or even prevent
the chances of developing metabolic acidosis (chemical imbalance), which may
later pave the way for kidney dysfunction, muscle wasting and osteoporosis.
"Women facing kidney surgery should investigate
whether partial kidney removal is an option to treat their disease as it may
help prevent bone brittleness. Too often urologists have done radical
nephrectomies for patients who were candidates for partial nephrectomy. While
partial nephrectomy is more complex for the surgeon to perform, it can offer
better quality of life later in life," said Christopher Kane, MD, Professor of
Surgery, C. Lowell and JoEllen Parsons Endowed Chair in Urology and Chief of
the Division of Urology, and paper co-author.
About the Team
The UC San Diego team of researchers has one of
the best kidney preservation rates in the USA. They use robotic technology to
carry out partial nephrectomies to patients who would have, earlier, gone in
for the traditional surgery.
Derweesh is a nationally-acclaimed surgeon who
is committed to preserving kidney function in patients undergoing kidney cancer
Fellow researchers of Derweesh include at
UC San Diego Aditya Bagrodia, Reza Mehrazin, Wassim M. Bazzi, Jonathan
Silberstein, John B. Malcom, Sean P. Stroup, Omer Raheem, Robert W. Wake,