Vemurafenib Improves Survival in Advanced Malignant Melanoma

by Dr. Simi Paknikar on  March 6, 2012 at 2:14 PM Health In Focus
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A new drug, vemurafenib, has recently been approved by the European Union for use in patients with advanced malignant melanoma with BRAF mutation. The drug was already approved by the FDA in 2011 and was in use in some countries.
Vemurafenib Improves Survival in Advanced Malignant Melanoma
Vemurafenib Improves Survival in Advanced Malignant Melanoma

Malignant melanoma is a life-threatening skin cancer that could arise following excessive sun exposure or exposure to ultraviolet radiation. Patients have a poor prognosis if the cancer has spread to other organs; one in every four such cases may survive over a year.

Nearly 50% of malignant melanoma patients have a mutation called BRAF mutation. The BRAF protein plays a role in cell growth and survival. Mutation in the BRAF protein leads to excessive cell growth and cancer. Most of BRAF mutations are due to substitution of glutamic acid for valine at codon 600 (BRAF V600E). A test called the cobas 4800 BRAF V600 Mutation Test is used to diagnose the mutation.

Vemurafenib is an inhibitor of some mutated forms of BRAF protein. Thus, it is effective in malignant melanomas in people who show the presence of BRAF mutations.

In a small study, patients with advanced malignant melanoma who received prior treatment were followed up for a variable duration to a maximum of 20 months to study the overall response rate to the drug, the duration of response and overall survival. A total of 132 patients were included in the study.

The study found that nearly half the patients responded to treatment, most of them partially but 6% showed a complete response. The mean survival duration was an average of 15.9 months.

The most common side effects observed were joint pain, rash, increased sensitivity to sun, fatigue and loss of hair. A type of skin cancer called squamous cell carcinoma was diagnosed in 26% patients.

Thus, vemurafenib could provide hope to patients of advanced malignant melanoma with poor chances of survival.

Reference:

1. Survival in BRAF V600-Mutant Advanced Melanoma Treated with Vemurafenib; Jeffery Sosman et al; N Engl J Med 2012; 366:707-714

Source: Medindia

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