with early stage non-small cell lung cancer
with squamous cell carcinoma who undergo Stereotactic Body Radiation Therapy
(SBRT) have a higher rate of local failure when compared to other non-small
cell lung cancer patients.
- The effect of
stereotactic body radiation therapy (SBRT) on different types of lung cancer was studied by scientists
from the Cleveland Clinic.
- Squamous cell carcinoma patients
had two times the risk
of local failure after SBRT when compared to patients with adenocarcinoma.
- These findings can be used to optimize treatment for lung cancer
patients based on the cells of origin.
This study conducted by a group of researchers
from The Cleveland Clinic will help tailor treatment plans based on the type of
is the most common form
of cancer and is the most common cause of cancer-related death in the
- It accounts for 13% of all new
cancer cases worldwide
- It accounts for 19% of cancer-related
death in the world
- About 1.8 million new
lung cancer patients were detected in 2012
- Lung cancer
constitutes 6.9% of all new cancer cases in India
constitutes 9.3% of all cancer-related death in
- It is the most common form of cancer and cancer-related
death among men
- In India, Mizoram has the highest incidence
of lung cancer
The two main types of
lung cancer are
- Non-Small Cell Lung Cancer (NSCL)-
80-85% of lung cancer falls under this category.
- Small Cell Lung Cancer - constitutes
10-15% of lung cancer
NSCL are grouped into
three subtypes based on their cells of origin.
- Squamous cell carcinoma
: It constitutes 25 to 30% of all lung
cancers. They originate in squamous cells that are flat cells which are present
in the inner lining of the airways of the cells. Smokers are known to get this
type of cancer and include a main airway like bronchus.Adenocarcinoma:
It constitutes 40% of all lung cancers and are formed in cells that
normally secrete mucous. Large cell carcinoma: It constitutes 10 to 15% of
all lung cancers. It could form in any part of the lung.
for Lung Cancer
is considered during the early stages of lung
cancer (stage I and II).
However, surgery may not be possible always and
depends on -
- Age of the
- Medical co-morbidity
of the tumor
When surgery is not
possible stereotactic body radiation therapy
or SBRT is used as it
is a non-invasive, high precision radiation delivery mechanism
‘The use of stereotactic body radiation therapy (SBRT) optimized based on histological origins of cancer will provide greater benefits. Adenocarcinoma type of lung cancer have better outcome with radiotherapy.’
of Histological Subtype and Tumor Heterogeneity on SBRT Treatment
Cleveland Clinic, U.S, analyzed 740 patients who underwent SBRT during the
period 2003 to 2015 to identify the impact of histological subtype and
heterogeneity of the tumor on SBRT treatment outcomes.
The patients were
grouped into 4 categories
- Squamous cell
- Unknown- These included people who did not
have a biopsy-30%
- Non-small cell lung
The patients were
balanced for age, radiation rate, sex, body mass index (BMI) and
performance status. The analysis carried
out by the scientists showed that squamous cell carcinoma, younger age, higher BMI, few medical co-morbidities, higher
positron emission tomography (PET) and lower dose of radiation were associated
with an increased risk
of local failure.
analysis was used to calculate the strongest predictor of local failure, it was found that squamous cell carcinoma
histological subtype was the strongest predictor at a rate that was significantly
higher than people with
This is one of the first
studies that analyzed the effect of SBRT on histological sub-types of cancer,
according to the authors. Squamous cell
carcinomas had a higher rate of failure than other types of NSCLC.
study found that the local failure of squamous cell carcinoma was two fold
higher than adenocarcinoma.
Body Radiation Therapy (SBRT)
SBRT is a radiation
therapy that is used for tumors outside the central nervous system. In this
treatment procedure, a specialized co-ordination system is used for the exact
localization of the tumors in the body. Ether a single high dose radiation
treatment is delivered or a few fractionated treatment procedures are
This form of therapy
requires specialized beam of radiation delivered at different angles which
requires special radiation oncologists to carry out the procedure.
SBRT is administered for
those cancers that are not easily accessible or are present in underlying
tissues. The current study evaluated the benefit of using SBRT on the different
types of non-small cell lung cancer, which is the first study on the difference
in outcome based on histological differences. The study found conclusively that adenocarcinomas had a two time lower
risk of local failure when treated with SBRT when compared with squamous cell
study can be used to optimize treatment for non-small cell lung cancer based on
histological origins of the cancer.
- Lung cancer: Prevalent trends & emerging
concepts - (https:www.ncbi.nlm.nih.gov/pmc/articles/PMC4405940/)
Is Lung Cancer - Non-Small Cell? Topics - (http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/non-small-cell-lung-cancer-what-is-non-small-cell-lung-cancer)