Overweight and obese persons do
not get the much touted benefits of red wine. Resveratrol, a silent ingredient
in red wine, grabbed international fame owing to its medical potential. People
with diabetes, dementia and heart diseases are likely to be benefited from
resveratrol. However, an abnormally high body mass index (BMI) doesn't
qualify one to reap these benefits.
A landmark study done in Denmark
found that obese persons who took 1,500 mg of resveratrol per day for four weeks were no different from
those who didn't take supplements, in terms of the changes made to insulin levels,
blood pressure, cholesterol and energy expenditure. This proves wrong the
older claims. Various studies in animal models had previously confirmed the
impact of the compound on aging, obesity and diabetes. Resveratrol activates
cell proteins called sirtuins and promotes the production of mitochondria (the
power houses of a cell)
. The impact on obese individuals has been
challenged by the new study.
The potential benefits of the red wine ingredient
have always raised eyebrows globally. The anti-ageing effect of resveratrol by
activation of SIRT1 protein has been proved and disproved multiple times. While
Konrad Howitz and David Sinclair
of the Harvard Medical School cling on
to the anti-ageing effects, Pfizer and Amgen
have failed in proving
these. Authorities like the Mayo Clinic confirmed the 'bad cholesterol'
lowering (i.e. low density lipoprotein, LDL) effect of the compound. It may
lower the diseases of blood vessels arising due to high cholesterol levels.
Only time can prove what the reality is, whether
resveratrol actually serves well or is it just a hoax. Well for now, the latest
finding advocates us to maintain a healthy weight so as to benefit from a glass
of red wine.
Exploring the Promise of Resveratrol: Where Do
We Go From Here? Jill
P. Crandall and Nir