Hospital infections and cross-infections are a common
phenomenon seen in many clinical set-ups. Infections amongst the
immune-compromised cases are usually found to be difficult-to-treat as compared
to other patients. While there are a number of antibiotics to treat these
different infections, a higher difficulty is faced with the variants of
bacteria that are antibiotic-resistant. One of such culprits is Pseudomonas aeruginosa
is a strain of bacteria that causes some sinister and devastating
infections amongst animals as well as humans. It is commonly found on most
surfaces including hospital equipments. The bacteria are found inside ICUs and
frequently affect the immune-compromised patients. Some commonly caused
infections include urinary tract infections (UTI), pneumonia, colitis, bleeding
As part of ongoing
researches to identify ways to deal with the bacteria, a new study has
suggested that certain glycoproteins found in edible seeds-known as
lectin-blocking glycodecoys can help fight against these bacteria in both
animals as well as humans.
The researchers suggested that anti-adhesion treatment is
one of the most important methods to treat P.
infections amongst cases of cystic fibrosis and the
immune-compromised. P. aeruginosa
binds to the target cells by adhering to these cells by the production of
lectins. Anti-adhesion treatments involve the use of glycodecoys that compete
with these lectins to bind with the target cells. This prevents the adhesion of
these lectins to the target cells.
The researchers probed for the presence of these
glycodecoys in edible-seeds. Hemagglutination-inhibition test was used for the
detection of these glycodecoys.
found the presence of these glycodecoys in edible seeds including cocoa, tomato
seeds, cashew, coffee and pumpkin
. It was observed that these glycodecoys
protect the embryos of these edible seeds from infections.
It was suggested that these glycodecoys can also be used for preventing
infections amongst humans and animals. Further research is required in
Preventing Pseudomonas aeruginosa and Chromobacterium violaceum infections by
anti-adhesion-active components of edible seeds; Ofra Rachmaninov et al; BMC