- Eczema is a skin
condition that causes inflammation, redness, and itching.
- The Food and Drug
Administration has approved a new powerful drug called Dupilumab for
injection had a greater response rate than placebo in terms of safety and
efficacy in treating moderate-to-severe eczema.
The United States Food
and Drug Administration (FDA) has recently approved Dupilumab injection for the
treatment of moderate-to-severe eczema.
Eczema or dermatitis is
a condition that causes skin inflammation and swelling. It may also lead to
dry, itchy skin
and rashes in the face, on the insides of
elbows, and behind the knees.
‘The new powerful Dupilumab drug has been approved by the FDA for treating moderate-to-severe eczema.’
The FDA has granted Break
approval to the Dupilumab drug, which means the drug is
capable of treating a serious health condition. Preliminary clinical evidence
has proved that the drug is capable of showing significant improvement when
compared to the available therapies.
Dupilumab drug is
intended to be used for patients whose eczema is not controlled by any topical
therapies or specifically in patients for whom the topical therapies are not
advisable. Dupilumab drug is an antibody and the active ingredient of the
injection Dupixent that has currently been approved.
The drug can be used
either with or without topical corticosteroids.
Julie Beitz, M.D.,
director of the Office of Drug Evaluation III in the FDA's Center for Drug
Evaluation and Research, said, "FDA's approval of Dupixent demonstrates our
commitment to approving new and innovative therapies for patients with skin
can cause significant skin irritation and discomfort for patients, so it is
important to have a variety of treatment options available to patients,
including those patients whose disease is not controlled by topical therapies."
Testing the Efficacy
of Dupilumab Drug
The efficacy and the
safety of Dupilumab drug were studied by carrying out three placebo-controlled
clinical trials. About 2,119 people with atopic dermatitis (a common type of
eczema), who did not respond properly to topical medications, were considered
for the trials.
The findings revealed
that people who received Dupilumab drug had a clear or almost clear skin. These
people also had a reduction in skin itching after 16 weeks of treatment.
Dupilumab drug showed a
greater response rate when compared to the placebo control in the trials.
While the safety and
efficacy of Dupilumab drug were not well-known in the treatment of asthma
patients. It is to be noted that asthma patients must not stop or adjust their
medication dose without consulting their physicians.
Dupilumab drug is an
antibody that is available under the brand name Dupixent. It is administered in
the form of an injection under the skin.
The drug is capable of
binding to a protein (interleukin-4 (IL-4) receptor alpha subunit (IL-4Ra))
which causes inflammation. It mainly acts by binding to the protein and
inhibiting the inflammatory response.
Some of the common
side effects of the drug include
Dupilumab drug may also
result in serious allergic reactions which could lead to pink eye
(conjunctivitis) or inflammation of the cornea (keratitis). Patients are
immediately advised to consult a doctor if they experience any redness, itching
or visual changes.
What is Eczema?
Eczema is a condition
that causes skin inflammation. Atopic dermatitis
is a chronic
skin inflammatory disease and is the most common form of eczema. It can be
caused by a combination of genetic, immune or environmental factors.
Symptoms of Eczema
- Dry or sensitive
- Skin itching
- Areas of swelling
- Scaly patches of
- Oozing of fluids
- Crusty, thickened
Interesting Facts on
- Parents who have allergies,
asthma or eczema are more likely to influence or pass on eczema to their
- Eczema is more prevalent among people who
live in colder climates.
- Dairy products, nuts, shellfish may
sometimes be the cause for severe eczema.
- There is no definite cure for eczema.
However, treatment options may provide relief from symptoms.
- FDA approves new eczema drug Dupixent -
- FDA approves new eczema drug Dupixent -
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