The war on aging keeps
getting increasingly sophisticated with more and more scientific brains pouring
in. Treatment protocols incorporating multiple product regimens and rigorous
clinical testing have produced a new cosmetic anti-aging regimen that
effectively fights face wrinkles. When weighed against a recognized
topical treatment for facial wrinkling, the cosmetic regimen was found to have
good efficacy and was better tolerated by patients during
The road to being
gorgeous is getting more sophisticated day by day. The ever booming cosmetic
industry puts in tremendous efforts to develop the ultimate solution for aging.
current size of the Indian cosmetic industry alone is about US $600 million.
global billion dollar industry keeps imbibing the latest advancements in areas
of skin biology and clinical research. Advents in genomics have led to better
understanding of skin disease and aging processes at the genetic level. Dermatologists,
patients, and oversight organizations increasingly demand for 'scientifically sound' demonstrations of
efficacy whenever new cosmetics are developed. This has led to rigorous
clinical trials and robust study designs.
New cosmetic anti-agents
work at genetic levels and improve skin barrier function, promote normal/natural exfoliation and skin turnover, help
control reactive oxygen species and oxidative stress, and help maintain
consistent synthesis and replacement of extracellular structural components.
The key product
ingredients of the new regimen were identified based on an understanding of the
aging mechanisms at genomic levels.
The products when used
in a regimen format provide optimum benefits. The niacinamide/peptide/retinyl
propionate (NPP) regimen consisted of a lotion to be applied daily in the
morning and a night cream to be applied daily in the evening over the entire
face, and a specialized wrinkle product to be applied twice daily on areas of
concern. The efficacy of the cosmetic regimen was weighed against the FDA
in a 24-week clinical trial.
The study enrolled 196 Caucasian female
subjects aged 40 to 65 years with periorbital wrinkles. During an initial
2-week washout period, participants used a mild facial cleanser (OlayŪ
Face Wash) ad libitum and a facial moisturizer (OlayŪ
Complete All Day Moisture
Lotion Sensitive Skin SPF 15) twice daily. The new cosmetic wrinkle regimen was
weighed against topical tretinoin, the benchmark product for the mitigation of
fine facial wrinkles.
Tretinoin is an acid form of vitamin A and is
frequently used to treat acne.
Tretinoin cream has been approved by the FDA
for treating wrinkles. Treatment with tretinoin is associated with a poor
patient compatibility. Many patients discontinue its use prematurely due to
side effects such as redness and peeling of the skin that develop during the
first few weeks of application.
After an initial 8 weeks of treatment during the
study, 25 women from each group continued the treatment for an additional 16
The new regimen significantly improved facial
wrinkle appearance after 8 weeks; it was better tolerated than tretinoin during
this period. However, the effects as well as side effects of the new regimen
were similar to those of tretinoin after 24 weeks of treatment.
products are generally well-tolerated by the skin and acceptable by
patients. These are more 'pleasant for use' than topical therapies.
It is, however, generally
presumed that these products stand behind prescription topical therapies in
terms of clinical efficacy. The recent trial has proved otherwise.
Results of the trial thus prove that an
appropriately designed cosmetic regimen can improve the appearance of facial
fine lines and wrinkles without compromising aesthetics, skin tolerance, and
Practical Application of Genomics to the Development
of a Topical Cosmetic Anti-aging Regimen; Joseph Kaczvinsky et al; Skin Therapy