The harmful effects of excess cholesterol have been known for quite some time. Normal levels of cholesterol are essential for the body. HDL-cholesterol or good cholesterol
has a protective effect on the cardiovascular system. On the other hand, the levels of LDL-cholesterol or bad cholesterol, as well as of triglyceride should be kept in check. Excess amounts of bad cholesterol deposit within the walls of blood vessels. They narrow the lumen of the blood vessels, thereby reducing the blood supply to the particular part of the body that is supplied by the blood vessel. Reduction in blood supply could be particularly catastrophic if arteries supplying the heart muscle or the brain are affected. The patient could suffer from a stroke or a heart attack
, which could even be fatal.
‘Is it necessary to treat high levels of bad cholesterol in the elderly? A study indicates may be not as elevated levels of LDL cholesterol do not increase mortality risk.’
A new study indicates that high levels of
LDL-cholesterol in the elderly may not translate into an increased risk of
death in these individuals
. The study was based on
a literature search that included 19 published studies which assessed 68094
individuals aged 60 years or older.
found that high LDL-cholesterol levels were not linked to increased mortality
in elderly individuals over the age of 60 years. They found that most patients
with high LDL-cholesterol levels lived longer.
This study raises the question whether LDL-cholesterol is responsible for heart disease and death. This is in complete contrast to the current school of thought, where the notion is that atherosclerosis
starts in middle age and should therefore only worsen with advancing age, thereby proportionately contributing to a large number of deaths in older patients.
The researchers tried to explain their findings. One possible explanation is that LDL-cholesterol may have a protective effect against diseases caused or aggravated by microorganisms. For example, some viruses cause cancer, which is a common cause of death in the elderly. LDL-cholesterol may protect against these cancers
. Therefore, low LDL-cholesterol levels may increase the chances of fatal diseases, including cancer.
Drugs belonging to a group called statins
are commonly used for the treatment of high cholesterol levels. Though their protective effect is beyond doubt, some feel that they are being over prescribed. The researchers feel that guidelines regarding treatment of patients with high LDL-cholesterol levels to prevent cardiovascular disease may need re-evaluation in light of the results of this study.
The study is
likely to rake up some controversies, but may require further investigation.
Several experts have already raised doubts over the study. The study authors do
admit to some limitations, which could have possibly affected the results of
Till more is confirmed in this context, it is advised to follow the current guidelines which are based on large well-designed studies, and keep the levels of bad cholesterol under check with lifestyle changes
and medications where necessary.
U, Diamond DM, Hama R, et al. Lack of an association or an inverse association
between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open 2016;6: e010401. doi:10.1136/ bmjopen-2015-010401