Hypertension Therapy Reduces Cardiovascular Risk Regardless of Baseline Blood Pressure

by Vishnuprasad on  January 9, 2016 at 4:49 PM Health In Focus   - G J E 4
Blood pressure (BP) lowering treatment reduces the risk of major cardiovascular disease events regardless of baseline blood pressure, says a new study published in The Lancet.
 Hypertension Therapy Reduces Cardiovascular Risk Regardless of Baseline Blood Pressure
Hypertension Therapy Reduces Cardiovascular Risk Regardless of Baseline Blood Pressure

Blood pressure s the pressure exerted by circulating blood against the walls of blood vessels. It is measured in millimeters of mercury (mmHg). When your heart beats, it pushes blood through the arteries to the rest of your body. This force produces pressure on the arteries. This pressure is called systolic blood pressure (SBP) or top blood pressure.

‘The study identified a significant reduction in risk of major cardiovascular disease events including coronary heart disease, heart failure and stroke with every 10 mmHg cut in systolic blood pressure.’
A normal SBP is 120 mmHg or below. A top blood pressure of 120-139 mmHg indicates that you have normal blood pressure that is higher than ideal. Even individuals with this level are at a higher risk of developing heart disease. A SBP of 140 mmHg or higher, on repeated measurements, is considered to be .

The diastolic blood pressure number (DBP) or the bottom number is the pressure in the arteries when the heart relaxes between beats. A normal DBP number is 80 mmHg or less. The bottom number between 80 and 89 mmHg is normal but higher than ideal. A DBP of 90 mmHg or higher, on repeated examinations, is considered to be hypertension.

Hypertensive heart disease is one of the primary causes of death related to high BP. It refers to a group of disorders that includes heart failure ischemic heart disease, hypertensive heart disease, and left ventricular hypertrophy. Normal resting blood pressure is about 120/80 mm Hg.

The study gives solid support for lowering blood pressure and providing BP lowering medication to individuals with a history of cardiovascular disease, heart failure, coronary heart disease, chronic kidney disease, diabetes, and stroke.

In the study, researchers searched MEDLINE for large-scale blood pressure lowering trials, published between Jan 1, 1966, and July 7, 2015 and the medical literature to identify tests up to Nov 9, 2015.

The scientists found that cardiovascular disease risk reductions were proportional to the magnitude of BP reductions. The risks of coronary heart disease, heart failure and stroke were reduced for every 10 mmHg reduction in SBP, which bring into mutual or reciprocal relation with a significant 13% reduction in mortality in the populations studied.

In trials with higher and lower mean baseline SBP, similar proportional risk reductions were identified. "Our results provide strong support for lowering blood pressure to systolic blood pressures less than 130 mm Hg," researchers write.

The study observed no significant effect on renal failure. There was no clear evidence for variation in proportional risk reduction in major cardiovascular disease based on baseline disease history, except diabetes and chronic kidney disease, which correlated with smaller risk reductions.

Compared with other medications, β-blockers were inferior for prevention of major cardiovascular disease events; calcium channel blockers were found superior to other medications for stroke prevention. Common drugs used to treat high blood pressure include chlorthalidone, acebutolol, atenolol, benazepril hydrochloride, captopril, candesartan, amlodipine besylate, doxazosin mesylate, methyldopa, carvedilol, clonidine hydrochloride, guanadrel, hydralazine hydrocholoride,

Hypertension generally develops over many years, and it affects nearly everyone eventually. Fortunately, hypertension can be easily identified. Simple lifestyle changes like weight loss, lower sodium intake, moderate alcohol consumption, quit smoking, reduce stress levels can help control high blood pressure.


1. Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. The Lancet. 2015; doi:10.1016/S0140-6736(15)01225-8.

Source: Medindia

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