Resistant Staphylococcus aureus (MRSA) is the major cause for nosocomial
infections (hospital acquired infections).
- Scientists from
University of Tubingen, Germany have discovered a new antibiotic from
lugdunensis, produced a new antibiotic substance 'lugdunin' which was
found to be effective against MRSA infections.
- Human microbiome
proves to be a good source for the discovery of novel antibiotics.
German scientists have discovered a new bacteria from the human nose that is capable of producing an antibiotic substance which could treat dangerous superbugs like Methicillin Resistant Staphylcococcus aureus
The findings of the
early stage investigation on the discovery of a new class of antibiotics from
nasal bacteria for the treatment of drug resistant bacterial infections was
published in the journal Nature
‘Human microbiome is a good source for the discovery of new antibiotics. Staphylococcus lugdunensis from the human nose appears to be effective against MRSA infections.’
Staphylococcus aureus - Superbug
Staphylococcus aureus is a gram positive cocci that is mostly found in the nose, respiratory tract and the skin. The bacteria is capable of causing various illness ranging from minor skin infections like pimples and acne
to major life-threatening conditions like sepsis
, meningitis and endocarditis
. Antibiotics are used in the treatment of bacterial infections. Sometimes staphylococcus strains become resistant to antibiotics like penicillins
and cephalosporins. The Center for Disease Control and Prevention (CDC) has disclosed that 23,000 people die every year due to antibiotic resistant infections.
strains that are unable to resist antibiotics (particularly methicillin) are
classified under Methicillin Resistant Staphylococcus aureus (MRSA). This type
of staphylococcus aureus (MRSA) seems to be one of the major reasons for
nosocomial infections (hospital acquired infections) which kills about 11,000
people per year in the United States. MRSA is also known as the "Superbug"
because of the speed in which it transfers the antibiotic-resistant genes from
one bacterium to the other.
Research Study on
German researchers were trying
to find a new antibiotic which could kill the germs that already inhabit the
Andrew Peschal, the lead
scientist of the study and microbiologist at the University of Tubingen,
Germany, pointed out that the human nose is the most common entryway through
which MRSA enters the body.
The study which was
conducted using the nose swab of 37 people by Peschal and colleagues at the
University of Tubingen, Germany have found Staphylococcus lugdunensis bacterium
in the nostrils that can slowly stop the growth of the infectious bacteria
which is responsible for MRSA infections.
Researchers found that
the nostril dwelling bacterium Staphylococcus lugdunensis was able to produce
an antibiotic compound called ' lugdunin' which is capable of inhibiting the growth
of staphylococcus infections. They also showed the growth inhibitions on cell
cultures, mice skin and in the nose of cotton rats.
Researchers also said
that 'Lugdunin' is known to be the first example for a new class of peptide
This was further analyzed in 187 hospital patients and researchers were able to prove that
S.lugdunensis in the human nose was able to keep S. aureus at bay.
Human Microbiome - A
New Source for Antibiotics
Antibiotics were found
mostly from soil, living micro organisms and from the environment. In the
recent studies, researchers are finding new ways and trying to search for new
antibiotics inside the human body.
Dr. Nita Salzman, a
pathologist at the Medical college of Wisconsin said that the human microbiome is
a good source for producing novel antibiotics.
Peschel also said that
the human body has a lot of different ecological niches, and it might be the
right place for the discovery of new human antibiotics.
He also emphasized that the early stage findings of S. lugdunensis in the nostrils
would further require more research and clinical trials in order to
develop it into an antibiotic medicine for use.
- 'Nose-y' Bacteria Could Yield A New Way To Fight Infection - (http://www.npr.org/sections/health-shots/2016/07/27/487529338/nose-y-bacteria-could-yield-a-new-way-to-fight-
- Methicillin-resistant Staphylococcus aureus - (https:en.wikipedia.org/wiki/Methicillin-resistant_Staphylococcus_aureus)