Fructose-rich Diet Causes Liver Injury

by Dr. Simi Paknikar on  June 21, 2012 at 12:51 PM Health In Focus   - G J E 4
A study on rats concluded that administration of a diet rich in fructose leads to increased triglyceride and blood sugar levels and alters insulin resistance, possibly contributing to the development of metabolic syndrome. Fructose, in addition, reduces antioxidant activity and contributes to liver damage.
Fructose-rich Diet Causes Liver Injury
Fructose-rich Diet Causes Liver Injury

Fructose is an ingredient used in beverages as a sweetening agent. Studies have shown that metabolic syndrome is associated with intake of western diets rich in sugars and saturated fats.

Researchers from Brazil conducted a study to evaluate if a diet rich in fructose could alter metabolism in rats. The study was done on 28 rats divided into 2 groups. One group of rats was fed a fructose-rich diet over 8 weeks, while the second group was fed a normal diet. Some of the animals were euthanized at the end of the study to evaluate the effect of a high fructose diet on the liver and various metabolic parameters.

At the end of 8 weeks, it was found that the rats fed on fructose-rich had similar weights compared to those rats fed with a normal diet. The authors thus concluded that a high fructose diet does not cause short-term changes in weight.

The fructose-fed rats were found to have a reduced glucose tolerance and insulin sensitivity.

Their livers also showed high levels of triglycerides; fructose is normally converted into triglycerides in the liver.

The antioxidant activity was reduced in fructose-fed rats. Liver enzymes were also affected indicating liver damage. The liver damage was confirmed on microscopic examination of the liver.

This study on rats thus indicates that a diet rich in fructose could lead to liver damage and cause metabolic effects that may contribute to the development of metabolic syndrome.


1. Botezelli JD et al. Fructose consumption leads to reduced aerobic capacity and to liver injury in rats. Lipids in Health and Disease 2012, 11:78 doi:10.1186/1476-511X-11-78

Source: Medindia

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