CT Angiography Allows Safe Discharge of Patients With Possible Acute Coronary Syndrome from the Emergency Department

by Anne Trueman on  April 25, 2012 at 12:40 PM Health In Focus   - G J E 4
Acute coronary syndrome (ACS) refers to a group of symptoms that are attributed to obstruction of coronary arteries. In other words, it is a term that includes heart attack and unstable angina (a condition in which the heart doesn't get enough blood flow and oxygen).
 CT Angiography Allows Safe Discharge of Patients With Possible Acute Coronary Syndrome from the Emergency Department
CT Angiography Allows Safe Discharge of Patients With Possible Acute Coronary Syndrome from the Emergency Department

There is a specific type of heart attack, called non-ST elevation myocardial infarction, which does not show the diagnostic elevation on the ECG suggestive of a heart attack occurring. Acute coronary syndrome (ACS) is measured using a Thrombolysis in Myocardial Infarction risk score (TIMI). It categorizes a patient's percentage risk of all-cause mortality and new or recurring ischemic events.

Angiography is a non-invasive imaging procedure that can be performed faster than the cardiac catheterization and with less discomfort and speedy recovery.

The Coronary Computed Tomographic Angiography (CCTA) uses advanced CT technology (computed tomography) with intravenous (IV) contrast dye for obtaining three-dimensional high resolution pictures of blood vessels and heart. CCTA is also known as multi-slice computed tomography (MSCT), Cardiac CAT or Cardiac CT. Nowadays it is seen that emergency departments are crowded by patients with possible acute coronary syndromes.

However, for most of them the symptoms are ultimately found not to be of a heart disease. Although the coronary computed tomographic angiography (CCTA) is known to have negative predicitive ability in the identification of coronary diseases, its role in determining the safety of discharging patients from the emergency department is not well proven.

Harold Litt and colleagues, in a study published in New England Journal of Medicine 2012, assessed the effectiveness of CCTA for safe discharge of patients with possible acute coronary syndromes. For the purpose of study, CCTA or traditional care was randomly done on low-to-intermediate-risk patients with acute coronary syndromes in 2:1 ratio. 

The study involved 1370 patients aged above 30 years with a TIMI risk score of 0 to 2 and signs and symptoms that warranted admission or testing.

These patients were enrolled at the five study centers in the United States. Out of 1370 volunteers, 462 received traditional care while 908 received CCTA.

Results showed that in contrast to traditional care receiving group where 22.7 percent were safely discharged, patients in CCTA group had higher percentage (49.6 percent) of being discharged safely from the emergency department.

They had short duration of hospital stay and greater coronary disease detection rate. During the study no serious event was noted in either of the groups.

The study revealed the efficacy of CCTA in detecting coronary syndromes in low-to-intermediate-risk patients and promoted a speedy and safe discharge from the emergency department who would otherwise be admitted.

The study was funded by the Commonwealth of Pennsylvania Department of Health and the American College of Radiology Imaging Network Foundation.

Reference: CT Angiography for Safe Discharge of Patients with Possible Acute Coronary Syndromes; Harold Litt et al; N Engl J Med 2012; 366:1393-1403

Source: Medindia

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