tissue paper developed from bovine or porcine organs and could be useful for
several purposes including regenerative medicine and drug discovery
- A bioactive
tissue paper has been produced that can be folded, cut, sutured and even
stored in a refrigerator
- The paper
supports the production of hormones by ovarian follicles grown in it
- It also supports
the growth of bone marrow stem cells
research was published in Advanced
is being explored for the production of synthetic tissues and even entire organs
that can be used for transplantation
. It uses cells filled
in cartridges, referred to as bioink, which can be printed using 3D printers
resulting in an output of 3D tissues. Thus, it could be possible to print
organs using the patient's own cells in the future, which could be customized
for the patient and would avoid the problem of rejection. The more likely
immediate uses of bioprinting appear to be in the transplantation of skin and
blood vessels. Currently, experimental human blood vessels have been printed.
The bioactive tissue
paper was discovered accidentally following the spill of a 3-D printing ink. It
contains the protein that is located outside the cells, called extracellular
matrix. The protein was dried, powdered, and then combined with a polymer to
give it its final form.
Some of the properties
of the bioactive tissue produced by the scientists are as follows:
paper is thin but strong and pliable and can be easily folded, cut, rolled
or sutured, which makes it easy to use it during surgery. The
scientists have demonstrated its properties by making origami out of the
papers. It remains mechanically robust even when wet.
- It is made from organs like ovary, uterus,
heart, liver and muscle obtained from pigs or cows.
tissue supports the production of hormones by ovarian follicles. When
the ovarian follicles were grown in the tissue made from bovine ovary, the
follicles produced hormones. Thus, the tissue with the follicles could
possibly be inserted into the body of young cancer patients who have lost
their hormonal functions due to the cancer treatments like chemotherapy and radiotherapy. It could
also serve as a hormone replacement therapy
in menopausal women.
tissue can assist in wound healing and prevent scarring. Since
the paper holds the specific properties of the organ from which it is
obtained, it could provide the necessary biochemicals that are required
for tissue regeneration and support wound healing.
- When bone marrow stem cells (cells that can
give rise to other types of cells) were put on the tissue paper, the tissue paper supported the growth
of the cells, which multiplied on it.
- The paper
can be easily stored. It can be frozen in the refrigerator or
the freezer and used later when needed.
Though the tissue
appears to have favorable properties, it will be still some time before it can
be used in humans. The scientists feel that it has the potential to be used in
various fields like tissue engineering, regenerative medicine, drug discovery
- Jakus AE et al. "Tissue Papers" from Organ-Specific Decellularized Extracellular Matrices. DOI: