is the most
common form of dementia. Globally, death rates for the disease are increasing.
According to health experts, about
500,000 new cases are going to appear in the United States alone in the coming
concept that disorders of the brain vascular system played a vital role in the
causation and development of the disease were expressed a quite a long time
ago. It has been suggested that blood flow to the brain including in the small
vessels like capillaries could be affected in patients with Alzheimer's disease.
Details of the Study
examined as many as 165 patients with Alzheimer's
disease. After conducting examinations including clinical assessment of dementia
severity (CDR), cognitive function assessment (MMSE), blood tests and tests on
the brain, a total of 89 patients aged between 34 and 79 were selected for the
study which included 31 (34.83%) male, 58 (65.17%) female patients.
The patients were divided into
four categories according to their disease stage. There were as many as 10
patients in TDR-0 - preclinical stage, 28 in TDR-1 - early stage with mild
dementia, 34 in TDR-2 - medium stage with moderate dementia, 17 in TDR-3 - late
stage with severe dementia.
The test group with 46 patients
from different stages were given transcatheter
with low-energy lasers. During this treatment, a catheter
is introduced into an artery of the leg and is advanced into the arteries of
the brain, where the laser is administered.
The control group with 43 patients
had conservative treatment with the anti-Alzheimer drugs
or choline alfoscerate.
The test group had improved
microcirculation in the brain, which was demonstrated through angiographic
studies. They showed reduction in dementia
and recovery of cognitive function that
was reduced by Alzheimer's disease. Also, the treatment transferred some of
them to a lighter TDR group.
On the other hand, the control
group with earlier AD stages (TDR-0, TDR-1, TDR-2) were stable for a variable
period of 6 months-3 years. But they suffered a subsequent increase in dementia
and cognitive impairment
Moreover, the control group patients with late AD stage (TDR-3) showed further
deterioration in terms of dementia and cognitive impairment.
The researchers did not note any
major complications with the transcatheter laser treatment. Thus, they suggest
that this treatment is relatively safe and effective in treating patients of