A recent study has established an association
between IGOB131, a seed extract from Irvingia gabonensis, body weight
and other associated metabolic parameters in overweight human volunteers. IGOB131, positively impacts adipogenesis
through various metabolic pathways, which may include PPAR gamma, leptin,
adiponectin, and glycerol-3 phosphate dehydrogenase.
Excess of adipose or fat tissue increases
the risk of heart disease, diabetes, obstructive lung disease, arthritis and a
variety of cancers. Insulin resistance, caused either by environmental factors
like increase in body mass, diet or excess visceral fat, or genetic factors, is
the primary cause of metabolic syndrome that leads to cardiovascular disease. Diet restriction can help achieve weight
loss, which will ultimately improve the insulin action on target tissues like
skeletal muscle, liver and fat cells.
It has been found that biologically
active molecules like leptin, resistin, TNF-α, and
IL-6 contribute to obesity-linked metabolic abnormalities. As plasma leptin
levels are closely correlated with that of adipose tissue, the decreases in
plasma leptin level associated with IGOB131 treatment may be due to a decrease
of adipose tissue.
like epigallocatechin gallate with anti-obesity properties help to improve
metabolic disorders by modulating adipokines and growth factors, including
improving leptin function.
the active principles of IGOB131 have not yet been fully identified, it is
likely to contain some of the above mentioned compounds.
Earlier it was believed that the positive
changes in the metabolic parameters were due to the high fiber content of Irvingia
fruit, commonly used in Nigerian and Cameroonian
cuisine. However, results of subsequent analysis suggest that the beneficial
effects of Irvingia gabonensis
not be accounted by fiber content alone.
In a published study, 120 healthy and
overweight volunteers were selected, who were randomly divided in two groups.
While one group was given 150 mg of IGOB131, other received a matching
placebo half an hour before lunch and dinner. At regular intervals, the groups
were evaluated for any changes in metabolic parameters like fasting lipids, blood
glucose, leptin and adiponectin.
Though not much difference was noted in
the initial weeks, by the tenth week, significant differences were observed
between the placebo and experimental intervention groups, with respect to body
weight, body fat, waist circumference as well as plasma total cholesterol, LDL
cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels. Body fat decreased over time in both groups
but the experimental group lost significantly more body fat compared to the placebo
This study indicates that IGOB131 is associated with
an increase in plasma adiponectin level and decrease in leptin and CRP levels
along with a favorable impact upon adipogenesis.
Judith L Ngondi, Blanche C Etoundi, Christine B Nyangono, Carl MF Mbofung and
Julius E Oben. IGOB131, a novel seed extract of the West African plant Irvingia
gabonensis, significantly reduces body weight and improves metabolic parameters
in overweight humans in a randomized double-blind placebo controlled
investigation. Lipids in Health and Disease 2009, 8:7 doi:10.1186/1476-511X-8-7.