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Oral Drug Ferriprox Approved to Treat Excess Iron
Transfusional iron overload is usually treated with chelation therapy. Chelation therapy uses chemical agents that can remove heavy metals from the body. The modality does not work for all patients. Ferriprox has been approved for use when chelation therapy is inadequate.
Data from 12 clinical studies in 236 patients were analysed. Patients participating in the study did not respond to previous iron chelation therapy. Deferiprone was found to bring a 20% decrease in serum ferritin, a protein that stores iron in the body for later use. The drug was found to successfully reduce ferritin levels in half of the patients in the study.
The U.S. Food and Drug Administration (FDA), has listed the following side effects of Ferriprox:
Nausea
Vomiting
Abdominal and joint pain
Urine discoloration (chromaturia)
A decrease in the number of white blood cells (neutropenia)
An increase in the level of a liver enzyme that may be indicative of tissue or liver damage at unsafe amounts
2% of patients treated with Ferriprox developed a serious and potentially life-threatening condition called agranulocytosis. The number of granulocytes (a type of white blood cell that fights infection) falls dangerously in agranulocytosis.
Further uses of the drug are being probed into. ApoPharma, the company behind Ferriprox, has committed to study the effect of the drug in patients with sickle cell disease who have transfusional iron overload.
Reference: U.S. Food and Drug Administration (FDA)
Source-Medindia
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