Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Novel Combination Therapy For Asthma Found To Be Safe And Fast-Acting | |
|
| |
The novel fixed-dose drug combination of mometasone furoate
and formoterol fumarate (MF/F) may have the same efficacy as that of the commonly
prescribed fluticasone propionate/salmeterol (FP/S) combination in the
treatment of asthma. MF/F has a quicker onset of action compared with FP/S.
Asthma is a chronic inflammatory disease that causes the airways to swell and narrow. It results in recurrent coughing, chest tightness, wheezing, and breathlessness. More than 300 million people worldwide suffer from asthma, with over 80% of related deaths reported from low and lower-middle income countries. Asthma is a leading cause of morbidity and mortality in rural India.
Symptoms of persistent asthma are relieved by inhaled corticosteroid (ICS) drugs. When these drugs cannot control asthma alone, another category of drugs called long-acting β2-agonists (LABA) like salmeterol and formoterol is added. Mometasone furoate/formoterol is the most recent ICS/LABA combination therapy available for treating persistent asthma.
While most of the previous studies tested the safety profile of this combination therapy, none evaluated the efficacy in comparison with the commonly prescribed fluticasone propionate/salmeterol (FP/S) combination. MF/F is well tolerated and has a safety profile similar to FP/S.
A recently published study was a 12-week long multicenter trial in patients with uncontrolled persistent asthma previously treated with medium-dose ICS with or without a LABA. Factors assessed included lung function, asthma control, quality of life and symptoms, clinically-judged asthma deteriorations, and safety. (Asthma resulting in emergency treatment, hospitalization, or treatment with additional drugs defines clinically-judged asthma deteriorations.)
The results indicate that MF/F improves lung function and asthma control similar to FP/S. It also has a superior onset of action compared with FP/S.A faster onset of action is a highly desired characteristic required in asthma therapy, especially from a patient perspective. Patients are more likely to stick on to a medication that works fast and alleviates symptoms soon after initiating therapy. Treatment satisfaction is a requisite for any modality of disease management. Significant improvement in lung function was observed 5-30 minutes after delivery of MF/F via metered-dose inhaler (MDI).
Both the drug combinations are safe, well tolerated, and improve asthma control. MF/F, however, has a faster onset of action than FP/S.
Reference:
Efficacy and Onset of Action of Mometasone Furoate/Formoterol and Fluticasone Propionate/Salmeterol Combination Treatment in Subjects With Persistent Asthma
Allergy, Asthma & Clinical Immunology 2011, 7:21 doi:10.1186/1710-1492-7-21
Source-Medindia
| |
|
|
More News on: Childhood Asthma, Asthma, Reiki and Pranic Healing, Remedies for Seasonal Allergy Relief, Allergy - Symptom Evaluation, Combination Therapy for High Blood Pressure, Wheezing
 Comment & Contribute
|
Related Links
Cockroach Allergens Cause Aggravation of Asthma
Cockroach allergens may play key role in the development of the asthma epidemic. Mucosal exposure to allergens leads to ...
Asthma Treated Successfully With Lebrikizumab
Asthma is a complex disease marked by the inflammation of the respiratory tract leading to breathing difficulty. The condition is heterogeneous in ...
Asthma
It's a lung condition characterized by inflammation of the bronchi and constriction of the airways that result in coughing, wheezing or ...
Asthma Management - Animation
Metered Dose Inhalers(MDI), which delivers medictions directly to the lungs, can be most effectively used in the treatment of ...
Health In Focus News
Strenuous Working Environment Leads to Diabetes
According to the scientists working in strenuous environment, healthy individuals too are exposed to the threat of developing diabetes. ...
Discarded Kidneys Can Be Used to Generate New Kidneys for Transplantation - Dawn of a New Era in Regenerative Medicine Research
Researchers at Wake Forest Baptist Medical Center in the USA found that human kidneys discarded for transplant can potentially serve as a ...
Flavored Toothbrush for a Pleasant Morning
Toothbrushes are all set to take up a new role. They may soon deliver your morning coffee and get you up and alert even faster. Even more ...
Science Behind the Placebo Effect
Probably the most controversial, yet amazing aspect of medicine is the placebo effect. The idea that somehow, a simple sugar pill, or a drugless ...
Exposure to Toxic Waste can Ruin Health in Kids
Children dwelling at places with abundance of toxic waste in Indonesia, India and Philippines may develop high quantities of lead in their blood ...
Media Reports on Health Hazards May Affect the Health of Some People
Media reports on the adverse effects of substances or technologies can actually trigger the symptoms in some people who read the report, even ...
- Health News Index
|
|
- News Quick Links
 |
Asthma
Complete Medindia Resources
|
| News Categories: |
| » | Food Supplement from Beef, Oysters Fights Brain Disorders |
| » | Potatoes may be One of the Best Superfoods, Says Study |
| » | Amount of Calories in Fast Foods Underestimated by People |
| » | GM Tomatoes 'Tastier and Longer-lasting' |
| » | Dietary Advice on Added Sugar 'Damaging Our Health', Says Expert |
| More Diet News | |
|
Ask an Expert
