Starvation dieting can
trigger auto-cannibalism in the Brain, reports an article in Cell Metabolism.
You had better eat well or the brain will
start eating itself!
Research carried out by scientists at the Albert Einstein College of Medicine reports an act
of auto-cannibalism in the brain cells of those who starve themselves.
The phenomenon has been
reported as occurring in the neurons of the hypothalamus in mice. These neurons
are responsible for appetite regulation.
When
the mice starve, these neurons engage in autophagy, an activity whereby they
begin to eat themselves.
During this activity certain fatty acids are released, resulting in an increase
in production of the hunger-signaling peptide AgRP.
When the brain chomping session is stopped,
the hunger signals stop and the mice do not eat as much as they ate before and
thus, they manage to remain lean.
There is no room for apprehension with this
report as the auto-phagous process is not new to the body.
During lean times, the body is used to
consuming its own cells to conserve energy. But it was generally believed,
earlier, that the brain was exempted from this behavior.
"A pathway that is really important for
every cell to turn over components in a kind of housekeeping process is also
required to regulate appetite. Treatments aimed at the pathway might make you
less hungry and burn more fat, a good way to maintain energy balance in a world
where calories are cheap and plentiful," said study leader Dr. Rajat Singh.
The study is expected to help to produce
better and scientifically proven anti-obesity medications.
Indeed it looks like the dieters have a lot to look
forward to!Source-Medindia