Alcohol Exacerbates Skin Diseases and Psoriasis

by Dr. Shalini Aul on  June 18, 2011 at 2:28 PM Health In Focus   - G J E 4 View in Hindi
Alcohol can damage skin causing rosacea, porphyria cutanea tarda, post-adolescent acne, discoid eczema and psoriasis.
Alcohol Exacerbates Skin Diseases and Psoriasis
Alcohol Exacerbates Skin Diseases and Psoriasis

Alcohol consumption is known to cause multiple health problems which affect organs such as liver, heart, kidney, blood and bone marrow. It is also responsible for nutritional deficiencies and an overall decrease in immunity. Alcohol abuse has a deleterious affect on the skin and is responsible for causing various skin conditions like rosacea, porphyria cutanea tarda, post-adolescent acne, discoid eczema and psoriasis.

A recent article reviewed the direct and indirect changes of alcohol on the skin. Alcoholic liver abnormality disturbs the estrogen and bile salt metabolism with peculiar signs of inflammation and redness on the skin. In male alcoholics, there is an increase in the female hormone called estrogen and a decrease in the male hormone testosterone. This causes a feminizing effect such as development of breasts, feminine pattern of body and pubic hair and redistribution of body fat. Liver cirrhosis and portal hypertension account for the distinctive skin condition around the belly button called 'caput medusae' -distended veins.

Alcoholics tend to have an increase in systemic and superficial skin problems with bacterial and fungal infections. This is because of alcohol-induced nutritional deficiency and impaired absorption of zinc and vitamins from the intestines, which results in decreased immunity. The deficiencies of zinc, vitamin C and trace elements cause a weakening of mucosal barriers, poor wound healing and a tendency for infections.

Other abnormalities of the skin include fissuring in the corners of the lips, pinpoint bleeds due to vitamin B deficiency (called pellagra), development of red and purple hemorrhagic spots on the skin and a tendency for bruising easily.

A metabolic disorder known as "Porphyria Cutanea Tarda (PCT)" occurs due to the scarcity of one of the hepatic enzymes concerned in porphyrin metabolism, especially uroporpyrinogen decarboxylase. The build up of photoreactive porphyrin precursors causes extreme photosensitivity to the skin.

Alcohol, by acting on various enzymes, results in a flare up of porphyria cutanea tarda causing skin blisters and eruptions in sun-exposed areas which heal with scarring and milia (tiny white bumps in the skin).

Alcohol is also responsible for disturbing the center of the brain that control tone of blood vessels. Alcohol causes dilatation of skin vessels which increases the blood supply to the skin and gives the skin its distinctive redness and flushing. A genetic deficiency of an alcohol metabolic enzyme is also responsible for facial redness and erythema.

Psoriasis is a chronic inflammatory immune-mediated disease with multiple causative factors which affects skin too causing increased thickness of the skin due to its cells dividing more then they should normally. Evidently, alcohol abuse increases the possibility of aggravating or producing psoriasis.

Dr. Natalia Kazakevich from the Department of Dermatology, Weill Cornell Medical College at Texas has authored a study involving 82,869 women for 14 years indicates that the intake of more then 2.3 alcoholic drinks per week significantly increases the possibility of new onset psoriasis. The same study also found that the consumption of strong beer in females can singularly cause psoriasis. Similarly, an excessive intake of alcohol more than 100g daily increases the possibility of exacerbating and developing psoriasis in males.

Patients under medication for psoriasis taking alcohol have been reported to have a poor response to therapy. There is a peripheral involvement of the back of the hands and fingers in the psoriasis associated with profuse drinkers similar to that seen in immunocompromised individuals. There are many theories as to how alcohol provokes and aggravates psoriasis such as immune suppression, stimulating production of inflammatory cytokines and cell cycle activators which speed up the growth and multiplication of skin cells, and an increased propensity for superficial infections and damage.

To sum up, there is evidently an definite link between the contribution of alcohol and the development of skin problems including psoriasis. In case of psoariasis alcohol not only aggravates the disease but also causes resistance to the treatment. Medical treatment alone for a skin disorder is insufficient. Education and counseling about the effects of alcohol intake needs stressing and the patient requires constant reinforcement to ensure that he keeps away from his regular daily tipple.  

Source: Alcohol and Skin Disorders: With a Focus on Psoriasis; Natalia et al; Skin Therapy Letter. 2011;16(4).

Source: Medindia

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