At the upcoming 7th International Nanotoxicology Congress to be held, PETA International Science Consortium Ltd's nanotechnology experts are going to present a poster regarding hazard testing strategy, titled "Altered-testing strategy for nanomaterial hazard assessment".
Dr. Monita Sharma will outline a strategy consistent with the 2007 report from the US National Academy of Sciences, Toxicity Testing in the 21st Century: A Vision and a Strategy, which recommends use of non-animal methods involving human cells and cell lines for mechanistic pathway-based toxicity studies.
Based on the current literature, the proposed strategy includes thorough characterization of nanomaterials as manufactured, as intended for use, and as present in the final biological system; assessment using multiple in silico and in vitro model systems, including high-throughput screening (HTS) assays and 3D systems; and data sharing among researchers from government, academia, and industry through web-based tools, such as the Nanomaterial Registry and NanoHUB.
Implementation of the proposed strategy will generate meaningful information on nanomaterial properties and their interaction with biological systems. It is cost-effective, reduces animal use, and can be applied for assessing risk and making intelligent regulatory decisions regarding the use and disposal of nanomaterials.