Hazard Testing Strategy to be Presented by PETA Science Consortium at Nanotoxicology Meeting

At the upcoming 7th International Nanotoxicology Congress to be held, PETA International Science Consortium Ltd’s nanotechnology experts are going to present a poster regarding hazard testing strategy, titled "Altered-testing strategy for nanomaterial hazard assessment". Dr. Monita Sharma will outline a strategy consistent with the 2007 report from the US National Academy of Sciences, Toxicity Testing in the 21st Century: A Vision and a Strategy, which recommends use of non-animal methods involving human cells and cell lines for mechanistic pathway–based toxicity studies.

Based on the current literature, the proposed strategy includes thorough characterization of nanomaterials as manufactured, as intended for use, and as present in the final biological system; assessment using multiple in silico and in vitro model systems, including high-throughput screening (HTS) assays and 3D systems; and data sharing among researchers from government, academia, and industry through web-based tools, such as the Nanomaterial Registry and NanoHUB.

Implementation of the proposed strategy will generate meaningful information on nanomaterial properties and their interaction with biological systems. It is cost-effective, reduces animal use, and can be applied for assessing risk and making intelligent regulatory decisions regarding the use and disposal of nanomaterials.



Source-Eurekalert