'Hairless' Gene may be the Cause for Your Baldness

by Kathy Jones on  April 3, 2014 at 7:44 PM Genetics & Stem Cells News   - G J E 4
A genetic reason has been identified by researchers as being a cause of hair loss.
 'Hairless' Gene may be the Cause for Your Baldness
'Hairless' Gene may be the Cause for Your Baldness

This newly discovered molecular function likely explains why mutations in the hairless gene contribute to the pathogenesis of atrichia with papular lesions. In addition, this gene also has also been shown to function as a tumor suppressor gene in the skin, raising hope for developing new approaches in the treatment of skin disorders and/or some cancers.

To make their discovery, Angela M. Christiano, Ph.D., FACMG, a researcher involved in the work from the Departments of Dermatology and Genetics and Development at the Columbia University College of Physicians and Surgeons in New York, NY, and colleagues defined the histone demethylase function of the human hairless gene, both in vitro and using cultured human cells.

When the hairless protein was mixed with specific histone substrates under defined reaction conditions, the hairless protein causes a reduction in the level of methylation modification of the histone substrates.

Similarly, upon expression of normal hairless protein, but not a mutant form of the hairless protein, researchers observed a drastic loss of histone methylation in human cells. This suggests that this may be the "on/off" switch for hair growth as well as a promising target for some types of skin disease.

The study has been published in the The FASEB Journal.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions
Hie! I am Pranit Urankar, above news is very true that hairless gene may be a factor for your hair loss. I have been seeing people who fall short on hair are basically youth, and this problem is really catching fire in today's world. Some feel dejected as early hair loss results in bad personality, and the main reason for that is genetic problem, a problem which is hereditary. Please look for solution if you face hair loss at early age.Thank you!
clinicspots Saturday, August 22, 2015

You May Also Like