Medindia

X

Ginsenoside Rb1 Promotes Hippocampal Neuronal Neurite Outgrowth: Study

by Bidita Debnath on  July 19, 2014 at 11:12 PM Research News   - G J E 4
The main pathological changes of Alzheimer's disease (AD) include neurite outgrowth impairment and amyloid-beta protein-induced hippocampal neuronal injury.
 Ginsenoside Rb1 Promotes Hippocampal Neuronal Neurite Outgrowth: Study
Ginsenoside Rb1 Promotes Hippocampal Neuronal Neurite Outgrowth: Study
Advertisement

Phosphatidylinositol 3-kinase (PI3K)/Akt pathway and mitogen-activated protein kinase (MAPK) pathway are the important signaling pathways respectively responsible for regulating synaptic plasticity and neuronal survival.

Advertisement
In view of the fact that ginsenoside Rb1 exhibits anti-aging and anti-dementia effects, Prof. Qionglan Yuan and her team, Department of Anatomy & Neurobiology, Tongji University School of Medicine, Shanghai, China performed a study, in which ginsenoside Rb1 was used, and found that ginsenoside Rb1 promoted hippocampal neuronal neurite outgrowth and protected against neurotoxicity induced by amlyloid-beta (23-25) via a mechanism involving Akt and extracellular signal-regulated kinase 1/2 signaling.

Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014).

Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All