Ginger is a nontoxic, and very cost-effective source of medicine. Recently, researchers at the Atlanta Veterans Affairs Medical Center turned the ginger into what they are calling GDNPs, or ginger-derived nanoparticles. The research team, led by Dr. Didier Merlin with VA and the Institute for Biomedical Sciences at Georgia State University, believes the particles may be good medicine for Crohn's disease and ulcerative colitis, the two main forms of inflammatory bowel disease (IBD). The particles may also help fight cancer linked to colitis, the scientists believe.
‘Ginger-derived nanoparticles may be good medicine for Crohn's disease and ulcerative colitis, the two main forms of inflammatory bowel disease.’
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They report their findings, based on experiments with cells and mice, in the September 2016 issue of Biomaterials. Each ginger-based nanoparticle was about 230 nanometers in diameter. More than 300 of them could fit across the width of a human hair.
Fed to lab mice, the particles appeared to be nontoxic and had significant therapeutic effects:
- Importantly, they efficiently targeted the colon. They were absorbed mainly by cells in the lining of the intestines, where IBD inflammation occurs.
- The particles reduced acute colitis and prevented chronic colitis and colitis-associated cancer.
- They enhanced intestinal repair. Specifically, they boosted the survival and proliferation of the cells that make up the lining of the colon. They also lowered the production of proteins that promote inflammation, and raised the levels of proteins that fight inflammation.
Part of the therapeutic effect, say the researchers, comes from the high levels of lipids - fatty molecules - in the particles, a result of the natural lipids in the ginger plant. One of the lipids is phosphatidic acid, an important building block of cell membranes.
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Delivering these compounds in a nanoparticle, says Merlin's team, may be a more effective way to target colon tissue than simply providing the herb as a food or supplement.
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The group is looking at ginger, and other plants, as potential "nanofactories for the fabrication of medical nanoparticles."
Merlin and his VA and Georgia State University coauthors elaborated on the idea in a report earlier this year titled "Plant-derived edible nanoparticles as a new therapeutic approach against diseases." They wrote that plants are a "bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles."
Source-Eurekalert