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Genetic Mutations Responsible for Causing Leukemia Identified

by Raja Nandhini on  April 11, 2013 at 7:29 AM Genetics & Stem Cells News   - G J E 4
Researchers have identified the genetic mutations causing leukemia, a common type of cancer affecting children.

Researchers at The Institute of Cancer Research sequenced the entire set genomes of two sets of identical twins diagnosed with acute lymphoblastic leukemia.
 Genetic Mutations Responsible for Causing Leukemia Identified
Genetic Mutations Responsible for Causing Leukemia Identified
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It was found that the gene linked with leukemia ETV6-RUNX1 that was generated in the womb was similar in both the pairs of twins. There were 22 similar gene mutations in both pairs, which were not significant in development of leukemia.

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A mutation, called NF1, appeared in one pair of twins. This gene was inherited from their parents. The mutation predisposed the twins to neurofibromatosis, a condition that is considered a risk factor for leukemia.

The findings are published in the journal Proceedings of the National Academy of Sciences.

Source: Medindia
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