Medindia

X

Genetic Link to Rare Liver Disorder Identified

by Sheela Philomena on  April 22, 2013 at 3:15 PM Research News   - G J E 4
Specific genes associated with a rare liver disease has been identified by scientists.

The large-scale genetic study defines the relationship between primary sclerosing cholangitis and other autoimmune diseases.
 Genetic Link to Rare Liver Disorder Identified
Genetic Link to Rare Liver Disorder Identified
Advertisement

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.

Advertisement
Approximately 70 percent of people who suffer from PSC also suffer from IBD.

The team showed that only half of the newly associated genetic regions were shared with inflammatory bowel disease (IBD).

For the first time, this definitively proves that PSC, although genetically related to IBD, is a distinct disease.

PSC is a chronic, progressive disease of the bile ducts that channels bile from the liver into the intestines. It can cause inflammation of the bile ducts (cholangitis) and liver scarring that leads to liver cirrhosis and liver failure.

There are no effective treatments available.

Although PSC affects only one in 10,000 people, it is a leading cause of liver transplant surgery, reports Science Daily.

"Before our study, it was never quite clear whether PSC was a complication of IBD or a distinct disease in its own right," says Carl Anderson, lead author from the Wellcome Trust Sanger Institute, a genome research institute.

"We have proven it to be a unique disease, and hope that our results will inform the development of more effective treatments, designed to target the biological pathways involved in causing the disease".

Source: IANS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All