Novel Mapping Technique Renders Gene Therapy for Heart Disease With More Specificity

by Dr. Trupti Shirole on  November 18, 2016 at 10:24 AM Heart Disease News
RSS Email Print This Page Comment
Font : A-A+

Refractory angina is resistant to conventional therapies for coronary artery disease. Gene therapy to repair damaged heart muscle is most likely to succeed if it can be injected at the site of ischemia where there is viable myocardium with reduced contractile ability. A new technique that combines imaging and electroanatomical mapping does just that.
 Novel Mapping Technique Renders Gene Therapy for Heart Disease With More Specificity
Novel Mapping Technique Renders Gene Therapy for Heart Disease With More Specificity

A study of this novel approach that shows increased blood flow in treated areas in patients with refractory angina is published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Seppo Ylä-Herttuala, Kuopio University Hospital and University of Eastern Finland (Kuo-pio, Finland), together with coauthors Antti Kivelä, Antti Hedman, and Juha Hartikainen, and Antti Saraste and Juhani Knuuti, from Turku University Hospital, Finland, describe their method for targeted cardiac gene transfer in the article entitled "Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography".

The researchers use a combination of electromechanical mapping with a NOGA system and positron emission tomography (PET) radiowater perfusion imaging to create two-dimensional bull's eye maps that guide the injection of the gene therapy into the heart muscle. They target a site that has suffered ischemic damage, but is viable as shown by reduced contractile ability, to achieve the best possible outcome.

"Dr. Ylä-Herttualla's milestone clinical trial results demonstrate how gene therapy for heart disease can be rendered much more specific," says Editor-in-Chief Terence R. Flotte, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

DNA Finger Printing Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Body Mass Index Reiki and Pranic Healing Silent Killer Diseases Genetic Testing of Diseases Heart 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive