Gene Involved in Lipid Transport Linked to Cases of Familial Extreme Longevity

by Bidita Debnath on  August 28, 2014 at 11:31 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

In a recent report in Aging Cell, a multidisciplinary team of Spanish scientists identify rare variants in the APOB gene in several families where exceptional longevity (>100 years of age) appears to cluster.
 Gene Involved in Lipid Transport Linked to Cases of Familial Extreme Longevity
Gene Involved in Lipid Transport Linked to Cases of Familial Extreme Longevity

The team was led by Tim Cash and Manuel Serrano at the Spanish National Cancer Research Centre (CNIO). Investigators identified three Spanish families with at least two siblings of around 100 years of age and they sequenced their genes in the hope of finding rare variants that could be associated with extreme longevity. Remarkably, only one gene was found carrying rare variants in all the long-lived siblings of the three families, namely, APOB.

APOB is an attractive longevity gene because of its previous link to hypobetalipoproteinemia, a putative "longevity syndrome" and also because the protein encoded by APOB works in lipid transport together with the related protein APOE, which has common genetic variants with undisputed assocations with longevity.

This work is a first step in the identification of the genetic basis of familial extreme longevity and it points to cholesterol and lipid metabolism as an important determinant of human longevity.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Cholesterol DNA Finger Printing Cholesterol - The Enigma Chemical Tips to Live Longer Low Saturated Fat and Low Cholesterol Diet Lipid Profile Screening Weaver Syndrome Top Foods to Lower Triglycerides 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive