Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Gene Defect Responsible for Cancer Syndrome Discovered | |
|
| |
Researchers have identified germline BAP1 mutations linked to a novel cancer syndrome. Germline mutations are hereditary gene defects that are present in every cell.
The study investigated two unrelated families with BAP1 defects and found an increase in the occurrence of mole-like melanocytic tumors that are non-cancerous flat or slightly elevated and pigmented skin lesions. These benign skin lesions were found to carry the BAP1 mutation and it was concluded that people with this specific type of melanocytic lesion are at higher risk of developing melanoma and mesothelioma.
This discovery provides physicians with a visual marker in identifying individuals that may carry germline BAP1 mutations. People having this syndrome should reduce their exposure to environmental risk factors such as UV radiation for melanoma and avoid erionite and asbestos exposure for mesothelioma. It will also help identify individuals who are at higher risk for melanomas which is usually cured with timely detection and to assist in the early detection of mesothelioma which typically leads to better prognosis.
"Identifying this gene as a cause of several cancers can tell us who is at risk in a family before the cancer develops," said Michele Carbone, MD, PhD, director of the UH Cancer Center and professor of pathology, John A. Burns School of Medicine. "We can advise patients to undergo routine exams and genetic testing for early diagnoses and treatment." Carbone is the leading author of the paper included in the August 30, 2012 issue of the Journal of Translational Medicine, published by BioMed Central.
This novel gene-testing has been patented by Carbone and colleagues and is performed exclusively at The Queen's Medical Center in Honolulu, Hawaii where they receive genetic samples from across the entire United States. Carbone previously discovered that individuals who carry BAP1 mutations are susceptible to developing mesothelioma and melanoma of the eye. This latest discovery builds on this and other research on the BAP1 mutation.
Source-Eurekalert
| |
|
|
More News on: DNA Finger Printing, Cancer and Homeopathy, Cancer Facts, Cancer, Tattoos A Body Art, Weaver Syndrome
 Comment & Contribute
|
Related Links
Melanoma
Melanoma is the most dangerous type of skin cancer. It is a cancer that develops in melanocytes, cells which produce a skin pigment called ...
Research Identifies Skin Cancer for the First Time in Wild Fish Populations
New research has revealed widespread skin cancer that has been identified for the first time in wild marine fish populations. A ...
Mediterranean Diet Could Shield You from Deadliest Form of Skin Cancer
A Greek-style Mediterranean diet that is rich in antioxidants and omega-3 fatty acids could provide protection against even the deadliest form of ...
Cancer Related News
India Gets Advanced Breast Cancer Detecting Machine
In the national capital, an advanced digital breast cancer detecting machine with the capability to see the lesions in breasts with much more clarity ...
New Method can Help Distinguish Pancreatic Cancer from Pancreatitis
In a promising development that could help improve the accuracy of pancreatic cancer diagnosis, researchers at Mayo Clinic have come up with a new ...
Link Between Agent Orange Exposure and Prostate Cancer
A new study has now linked the exposure to Agent Orange and lethal forms of prostate cancer among the US Veterans. Published early online in ...
Tumour Growth Mechanism Goes a Step Further
New study suggests that loss of a particular tumour-suppressing protein causes abnormal growth of tumours of the brain and nervous system. ...
Link Between Skin Cancer and Lower Risk of Alzheimer's Disease Identified
According to a recent study people who have skin cancer are at a reduced risk of developing Alzheimer's disease. The link does not apply to melanoma, ...
Molecular Profiling Timely for Tailoring Therapy Shown By First Prospective Trial
Patients, and their physicians, are eager to jump into next-era cancer care analysis of an individual's tumor to find and target genetic mutations ...
- Health News Index
 | Quiz on Cancer Looking for information on cancer? Go through medindia's Cancer quiz. 
|
- News Quick Links
 | News Central | | Health Watch | |
| Latest Health News | | Health In Focus | |
| News Category (500+) | | Breaking Health News | |
| Popular News | | Celebrating Life | |
| Health News and Press Release | | Medindia - Exclusive | |
| News Photo Gallery | | India Special | |
| News Video Gallery | | Lifestyle and Wellness | |
| News From Other Resources | |||
 |
Cancer
Complete Medindia Resources
|
| News Categories: |
| » | Health Campaigners Hail Brave Angelina Jolie's Mastectomy Revelation |
| » | Angelina Jolie's Breast Removal Surgery Boosts Cancer Awareness, Experts Advise Caution |
| » | Shakira Having Sleepless Nights During Pregnancy |
| » | Belgian Nobel Laureate Christian De Duve Dies |
| » | Sherri Shepherd Owes Her Life to Diabetes |
| More Celebrity News | |
|
Ask an Expert
