Pregnant women exposed to high levels of pesticide DDT risk their daughters to breast cancer, reports a five-decade study done in US women.
"Environmental chemicals have long been suspected causes of breast cancer, but until now, there have been few human studies to support this idea," said Barbara Cohn of the Public Health Institute in Berkeley, California, co-author of the study.
DDT or dichlorodiphenyltrichloroethane synthesized in 1874 is a colorless, crystalline, tasteless and odorless organochloride known for its insecticidal properties.
Researchers examined a group of women who were exposed in utero to DDT in the 1960s, in the United States. The data came from a California program called Child Health and Development Studies (CHDS), which studied 20,754 pregnancies among women who were members of the Kaiser Foundation Health Plan from 1959 through 1967.
"This 54-year study is the first to provide direct evidence that chemical exposures for pregnant women may have lifelong consequences for their daughters' breast cancer risk."
Stored blood samples from 118 mothers who had daughters diagnosed with breast cancer by age 52 gave scientists a picture of how much DDT exposure they had when pregnant or shortly after giving birth.
"Independent of the mother's history of breast cancer, elevated levels of DDT in the mother's blood were associated with a nearly four-fold increase in the daughter's risk of breast cancer," said the study.
"Among the women who were diagnosed with breast cancer, 83 percent had estrogen-receptor positive breast cancer, a form of cancer that may receive signals from the hormone estrogen to promote tumor growth."
Women in the highest exposure group were also more likely to be diagnosed with advanced cancer than women who were not exposed to DDT. The chemicals in DDT are known to be endocrine disruptors, which can mimic and interfere with the function of the hormone estrogen.
Previous research has linked DDT exposure to birth defects, reduced fertility and increased risk of Type 2 diabetes.
"Our findings should prompt additional clinical and laboratory studies that can lead to prevention, early detection and treatment of DDT-associated breast cancer in the many generations of women who were exposed in the womb," said Cohn.