Kidney stones affect just over 7% of adults, and that number
has been on the rise. Though previous studies have identified a
long-term risk of chronic kidney disease in kidney stone formers, prior
research has not assessed kidney function immediately after their first
Mayo Clinic nephrologists have uncovered a connection between
first-time kidney stone formers and chronic kidney disease. In a paper
published today in Mayo Clinic Proceedings
, researchers announce a persistent decline in kidney functioning following an individual's first case of kidney stones.
‘There is a persistent decline in kidney functioning following an individual's first case of kidney stones, revealed a new study.’
A Mayo Clinic team led by William Haley and Andrew Rule assessed a group of 384 stone formers three months after their
first stone event to study the effect of kidney stones on their kidney
function. Compared to the control group, kidney stone formers maintained
higher levels of the blood marker cystatin C and higher levels of urine
protein - both of which are connected with higher risk of chronic
"Even after adjusting for other risk factors, including urine
chemistries, hypertension and obesity, we still found that those with a
kidney stone episode had subsequent abnormal kidney function," says Dr.
Rule. "This helps us better understand the long-term implications of
kidney stones beyond recovery time."
The small, hard mineral deposits that characterize kidney stones can
cause severe pain, nausea and difficulty passing urine. An increased
risk of chronic kidney disease, however, could make the condition one
that has a more long-term impact on an individual's health.
"This research shows that the implications of kidney stones may go
beyond the discomfort they are so often associated with," says Dr. Rule.
"Prevention of kidney stones may be beneficial for a person's overall