Few Peptides Influence Gonadotropin-releasing Hormone Neurons

by Bidita Debnath on  July 20, 2013 at 4:04 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Our understanding of this hypothalamus-pituitary-gonadal axis has quickly expanded during the last decade.
 Few Peptides Influence Gonadotropin-releasing Hormone Neurons
Few Peptides Influence Gonadotropin-releasing Hormone Neurons

Two novel hypothalamic Arg-Phe-amide- related peptides, kisspeptin and gonadotropin-inhibitory hormone, may be important regulators of the reproductive axis. Kisspeptins are currently recognized as the most potent activators of the hypothalamus-pituitary-gonadal axis. Kisspeptin and its receptor, G protein-coupled receptor 54 (GPR54), are expressed on gonadotropin-releasing hormone neurons, thus regulating the reproductive axis.

Kisspeptins strongly release gonadotropin- releasing hormone and luteinizing hormone, even at pre-puberty. Kisspeptin/GPR54 is important for the regulation of sexual maturation and the development of the reproductive system.

Prof. Haluk Kelestimur and colleagues from Medical School, Firat University, Elazig, Turkey used the GT1-7 cell line-expressing gonadotropin-releasing hormone as a model and found that gonadotropin-inhibitory hormone and Arg-Phe-amide-related peptide-1 may have inhibitory effects on kisspeptin-activated gonadotropin-releasing hormone neurons without affecting [Ca2+]i.

These findings which were in the Neural Regeneration Research (Vol. 8, No. 18, 2013) that Arg-Phe-amide-related-peptide-1, in addition to Arg-Phe-amide-related-peptide-3, may be involved in the modulation of the hypothalamus- pituitary-gonadal axis.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Parkinsons Disease Parkinsons Disease Surgical Treatment 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

Advertisement

News Category

News Archive