Highlights
- Higher levels of serum stearic acid/palmitic acid (S/P) ratio increased the chances of diabetes remission after bariatric surgery.
- S/P ratio may serve as a diagnostic //marker in preoperative patient assessment.
Endogenous fatty acid metabolism that results in elongation and desaturation lipid products is thought to play a role in the development of type 2 diabetes mellitus. Diabetics who undergo bariatric surgery have chances of recurrence but the reason remained unknown.
Jia and colleagues used two independent cohorts. The first was a longitudinal cohort of 38 obese patients with diabetes who achieved weight loss and diabetes remission after RYGB.
About 32 percent of these patients showed recurrence of diabetes at the second year follow-up examination. Those patients who had higher levels of S/P before surgery had greater possibilities for diabetes remission after surgery.
In the second cohort of 381 community-based human participants, overweight or obese patients with diabetes exhibited lower S/P than did body mass index-matched non-diabetic patients, which highlight the specific product-to-precursor ratios as novel markers in preoperative assessment of bariatric surgery.
"This is a very important new picture in the bariatric surgery field," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "Both the morbidity that necessitates the procedure and the procedure itself are steep challenges, and this study has the potential to greatly benefit patients going forward."
- Linjing Zhao et al., Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity, FASEB (2016) doi: 10.1096/fj.201600927R.
Source-Medindia