To predict a drug's side-effects on different patients, researchers at University of California, San Diego have developed a model.
"We are not just interested in predicting the efficacy of a drug, but its side-effects as well," said one of the researchers professor Bernhard Palsson. "Side-effects are very personalized. Two different people can take the same drug, but one person might experience side-effects while the other does not," Palsson noted.
‘Scientists used data from different people's genotypes to build personalized models that simulate how a drug will affect a particular set of cells in the body.’
The model predicts how variations in different people's genes impact how they metabolize a drug. Researchers used data from different people's genotypes and metabolism to build personalized models that simulate how a drug will affect a particular set of cells in the body.
"This is a unique approach to obtain personalized, predictive and mechanistic descriptions of people's physiology based on their genetic and metabolic makeup," Palsson explained. Researchers said this predictive model would be extremely useful for pharmaceutical companies during the drug development stage.
For example, pharmaceutical companies could conduct predictive screenings for drugs before clinical trials and determine which groups of patients would experience side-effects and which ones would not.
"This study is a step forward in demonstrating that patients could be precisely treated based on their genetic makeup," Palsson said. The findings appeared in the journal Cell Systems.