Obesity-related health problems may be reduced using a new therapy that involves engineered gut bacteria. A study conducted on mice found that engineered gut bacteria prevented weight gain and protected the mice against harmful health effects of obesity. More than one-third of the US adult population are obese. They are at increased risk for harmful effects of obesity such as fatty liver, heart disease and diabetes.
Microbes in the gut also known as gut microbiota play an important role in obesity and may offer a new therapeutic target. A research team led by Sean Davies, PhD, associate professor of pharmacology at Vanderbilt University studied whether obesity-related diseases might be treated or prevented by altering the gut microbiota.
‘In mice fed a high-fat diet, engineered gut bacteria prevented weight gain and reduced fat accumulation in the liver.’
The researchers engineered gut bacteria that produce a small lipid that suppresses appetite and reduce inflammation. Obese people produce low levels of this lipid, which is made by the small intestine.
"We had previously shown that this approach with engineered bacteria could inhibit obesity when standard mice were fed a high-fat diet," Davies said. "Our new studies focused on mice highly prone to develop atherosclerosis and fatty liver disease, and we showed that the engineered bacteria were beneficial not only in inhibiting obesity but also in protecting against fatty liver disease and somewhat against atherosclerosis."
Mice were fed a high-fat diet and also received the engineered bacteria via drinking water. The results showed that the mice gained less body weight and body fat when compared to mice given a standard drinking water or control bacteria.
Mice that are susceptible to atherosclerosis and fatty liver disease were given engineered bacteria. These mice accumulated less fat in the liver and showed reduced expression of markers of liver fibrosis, compared to mice that did not receive the treatment. The treated mice also exhibited a modest trend toward reduced atherosclerotic plaques.
"Some day in the future, it might be possible to treat the worst effects of obesity simply by administering these bacteria," Davies said. "Because of the sustainability of gut bacteria, this treatment would not need to be every day."
The researchers presented the findings at the American Physiological Society's Inflammation, Immunity and Cardiovascular Disease conference.