Endometriosis is a condition in which cells from the lining of the uterus (endometrium) are found elsewhere in the pelvic area. It is often associated with abdominal pain, heavy periods, and infertility. A new study has suggested that endometriosis may increase risk of miscarriage by over 75%.
The study comprised of over 14,000 women in Britain, with their medical records followed-up for a maximum of 30 years between 1981 and 2010. It was a nationwide cohort study using discharge data from all state hospitals in Scotland. Researchers cross-linked records of women with and without a confirmed diagnosis of endometriosis to their maternity records to evaluate pregnancy outcomes.
After adjustments for age and previous pregnancy, results showed that women with endometriosis had a significantly higher risk of early pregnancy complications than the control group. This risk was 76% higher for miscarriage and nearly three-times higher for ectopic pregnancy.
The researchers said, "The findings should now be taken into account when counseling women with endometriosis about their family plans and care during pregnancy."
Study's first author Lucky Saraswat, consultant gynecologist from the Aberdeen Royal Infirmary, Britain, said, "These results indicate that endometriosis pre-disposes women to an increased risk of early pregnancy loss and later pregnancy complications. Endometriosis is associated with increased inflammation in the pelvis, and structural and functional changes in the lining of the uterus. We believe such changes in the pelvic and uterine environment could influence implantation and development of placenta, predisposing them to adverse pregnancy outcomes."
The study will be presented at ESHRE 205, held in Lisbon, Portugal from June 14-17, 2015.